Comparative study of the effect of obesity on lipid profiles levels, insulin resistance and oxidative stress in adolescents
Keywords:
Oxidative Stress, Insulin Resistance, Dyslipidemia, Malandialdehyde
Abstract
Introduction: Obesity is associated with social and medical risks that especially make it a problem. The study is to determine whether the lipid abnormalities observed in obese adolescents are associated with insulin resistance & oxidative stress.
Methods: We evaluated the relationship between lipid levels and insulin resistance and oxidative stress in 30 female obese adolescents who were obese (body mass index > 25 Kg/m). Insulin resistance was assessed by fasting insulin and glucose level, Lipid profile was studied including, total cholesterol, HDL, LDL, and oxidative stress by estimating vitamin-c and Malandialdehyde.
Results: All the parameters except serum HDL level showed significant increase in obese adolescents persons while HDL level was significantly decreased.
Conclusion: The study indicates elevation of glucose, lipid profile levels and oxidative stress in obese adolescents. This is due to hyperinsulinaemia leads to insulin resistance. Insulin resistance may be responsible, for changes in lipid and lipoprotein concentration. childhood weight requires special early attention because insulin resistance, inflammation and dyslipidemia increase the risk of cardiovascular disease
Downloads
Download data is not yet available.
References
1. Plourde G. Impact of obesity on glucose and lipid profiles in adolescents at different age groups in relation to adulthood. BMC Fam Pract.
2. Roya Kelishadi, Mahin Hashemipour, Ahmad Sheikh-Heidar, and Shohreh Ghatreh in serum lipid profile of obese or overweight children and adolescents following a lifestyle modification courseARYA Atheroscler. 2012 Fall; 8(3):
3. Deshmukh-Taskar P, Nicklas TA SJ, Zakeri I, Berenson GS. Tracking of overweight status from childhood to young the Bogalusa Heart Study. Nutr. 2006 Jan;60(1):48-57.
4. P.L. Mendes, M.S. Maciel, L.F. Pinto, D.O. L.S. Conti, B.V. Mello, et al. The child obesity and the impact from childhood to adult life: a systematic review of scientific literature in the period 1997-2007 Pediatria (São Paulo)., 31 (2009), pp. 260 273.
5. Vykoukal D, Davies MG syndrome in a vascular patient. 2002 Oct 14;3:18. Ghatreh-Samani. Changes 143–148. TA, Morales M, Yang. adulthood:Eur J ClinSouza,child-adolescent260–MG. Biology of metabolicme Vascular. 2012Jun;20(3):156-65. doi: 10.1258/vasc.2011.201201. Epub 2012 Jun 14.
6. Evans DJ, Hoffmann RG, Kalkhoff RK, Kissebah AH. Relationship of body fat topography to insulin sensitivity and metabolic profiles in premenopausal women. Metabolism. 1984 Jan;33(1):68-75.
7. Krotkiewski M, Bjorntorp P, Sjostrom L, et al. Impact of obesity on metabolism in men and women: importance of regional adipose tissue distribution. J Clin Invest. 1983 Sep;72(3):1150-62.
8.Aroor AR, DeMarco VG2. Oxidative stress and obesity: the chicken or the egg? Diabetes. 2014 Jul;63(7):2216-8. doi: 10.2337/db14-0424.
9.Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972 Jun;18(6):499-502.
10.Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985 Jul;28(7):412-9.
11. Physical status: the use and interpretation of anthropometry. Report of a WHO Expert Committee. World Health Organ Tech Rep Ser. 1995;854:1-452.
12. Nitesh Mishra, Manoj Kumar Sharma. Central obesity and lipid profile in north indian males. International Journal of Applied Biology and Pharmaceutical Technology vol-3,issue-3,july-sep- 20121.
13.Serrano HM, Carvalho GQ, Pereira PF, Peluzio Mdo C, Franceschini Sdo C, Priore SE. [Body composition, biochemical and clinical changes of adolescents with excessive adiposity]. Arq Bras Cardiol. 2010 Oct;95(4):464-72. Epub 2010 Aug 13.
14.Costa GB, Horta N, Resende ZF, Souza G, Barreto LM, Correia LH, Nascimento TA, Rios CB, Barreto- Filho JA, Lopes HF. Body mass index has a good correlation with proatherosclerotic profile in children and adolescents. Arq Bras Cardiol. 2009 Sep;93(3):261- 7.
15. Palmer BF, Clegg DJ. The sexual dimorphism of obesity. Mol Cell Endocrinol. 2015;402C:113–119. doi: 10.1016/j.mce.2014.11.029.
16. Plourde G. Impact of obesity on glucose and lipid profiles in adolescents at different age groups in relation to adulthood BMC Family Practice. BMC Fam
Pract. 2002 Oct 14;3:18.
17. Stalder M, Pometta D, Suenram A. Relationshipbetween plasma insulin levels and high density lipoprotein cholesterol levels in healthy men. Diabetologia. 1981 Dec;21(6):544-8.
18. Pykälistö OJ, Smith PH, Brunzell JD. Determinants of human adipose tissue lipoprotein lipase. Effect of diabetes and obesity on basal- and diet-induced activity.
J Clin Invest. 1975 Nov;56(5):1108-17.
19. Sadur CN, Yost TJ, Eckel RH. Insulin responsiveness of adipose tissue lipoprotein lipase is delayed but preserved in obesity. J Clin Endocrinol Metab. 1984 Dec;59(6):1176-82.
20. Savage DB, Petersen KF, Shulman GI. Mechanisms of insulin resistance in humans and possible links with inflammation. Hypertension. 2005 May;45(5):828-33.
Epub 2005 Apr 11.
21. Esposito K, Ciotola M, Schisano B, Misso L, Giannetti G, Ceriello A, Giugliano D. Oxidative stress in the metabolic syndrome. J Endocrinol Invest. 2006 Oct;29(9):791-5.
22. Guilherme A, Virbasius JV, Puri V, Czech MP. Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nat Rev Mol Cell Biol. 2008 May;9(5):367-77. doi: 10.1038/nrm2391.
2. Roya Kelishadi, Mahin Hashemipour, Ahmad Sheikh-Heidar, and Shohreh Ghatreh in serum lipid profile of obese or overweight children and adolescents following a lifestyle modification courseARYA Atheroscler. 2012 Fall; 8(3):
3. Deshmukh-Taskar P, Nicklas TA SJ, Zakeri I, Berenson GS. Tracking of overweight status from childhood to young the Bogalusa Heart Study. Nutr. 2006 Jan;60(1):48-57.
4. P.L. Mendes, M.S. Maciel, L.F. Pinto, D.O. L.S. Conti, B.V. Mello, et al. The child obesity and the impact from childhood to adult life: a systematic review of scientific literature in the period 1997-2007 Pediatria (São Paulo)., 31 (2009), pp. 260 273.
5. Vykoukal D, Davies MG syndrome in a vascular patient. 2002 Oct 14;3:18. Ghatreh-Samani. Changes 143–148. TA, Morales M, Yang. adulthood:Eur J ClinSouza,child-adolescent260–MG. Biology of metabolicme Vascular. 2012Jun;20(3):156-65. doi: 10.1258/vasc.2011.201201. Epub 2012 Jun 14.
6. Evans DJ, Hoffmann RG, Kalkhoff RK, Kissebah AH. Relationship of body fat topography to insulin sensitivity and metabolic profiles in premenopausal women. Metabolism. 1984 Jan;33(1):68-75.
7. Krotkiewski M, Bjorntorp P, Sjostrom L, et al. Impact of obesity on metabolism in men and women: importance of regional adipose tissue distribution. J Clin Invest. 1983 Sep;72(3):1150-62.
8.Aroor AR, DeMarco VG2. Oxidative stress and obesity: the chicken or the egg? Diabetes. 2014 Jul;63(7):2216-8. doi: 10.2337/db14-0424.
9.Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972 Jun;18(6):499-502.
10.Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985 Jul;28(7):412-9.
11. Physical status: the use and interpretation of anthropometry. Report of a WHO Expert Committee. World Health Organ Tech Rep Ser. 1995;854:1-452.
12. Nitesh Mishra, Manoj Kumar Sharma. Central obesity and lipid profile in north indian males. International Journal of Applied Biology and Pharmaceutical Technology vol-3,issue-3,july-sep- 20121.
13.Serrano HM, Carvalho GQ, Pereira PF, Peluzio Mdo C, Franceschini Sdo C, Priore SE. [Body composition, biochemical and clinical changes of adolescents with excessive adiposity]. Arq Bras Cardiol. 2010 Oct;95(4):464-72. Epub 2010 Aug 13.
14.Costa GB, Horta N, Resende ZF, Souza G, Barreto LM, Correia LH, Nascimento TA, Rios CB, Barreto- Filho JA, Lopes HF. Body mass index has a good correlation with proatherosclerotic profile in children and adolescents. Arq Bras Cardiol. 2009 Sep;93(3):261- 7.
15. Palmer BF, Clegg DJ. The sexual dimorphism of obesity. Mol Cell Endocrinol. 2015;402C:113–119. doi: 10.1016/j.mce.2014.11.029.
16. Plourde G. Impact of obesity on glucose and lipid profiles in adolescents at different age groups in relation to adulthood BMC Family Practice. BMC Fam
Pract. 2002 Oct 14;3:18.
17. Stalder M, Pometta D, Suenram A. Relationshipbetween plasma insulin levels and high density lipoprotein cholesterol levels in healthy men. Diabetologia. 1981 Dec;21(6):544-8.
18. Pykälistö OJ, Smith PH, Brunzell JD. Determinants of human adipose tissue lipoprotein lipase. Effect of diabetes and obesity on basal- and diet-induced activity.
J Clin Invest. 1975 Nov;56(5):1108-17.
19. Sadur CN, Yost TJ, Eckel RH. Insulin responsiveness of adipose tissue lipoprotein lipase is delayed but preserved in obesity. J Clin Endocrinol Metab. 1984 Dec;59(6):1176-82.
20. Savage DB, Petersen KF, Shulman GI. Mechanisms of insulin resistance in humans and possible links with inflammation. Hypertension. 2005 May;45(5):828-33.
Epub 2005 Apr 11.
21. Esposito K, Ciotola M, Schisano B, Misso L, Giannetti G, Ceriello A, Giugliano D. Oxidative stress in the metabolic syndrome. J Endocrinol Invest. 2006 Oct;29(9):791-5.
22. Guilherme A, Virbasius JV, Puri V, Czech MP. Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nat Rev Mol Cell Biol. 2008 May;9(5):367-77. doi: 10.1038/nrm2391.
CITATION
DOI: 10.17511/ijmrr.2015.i9.172
Published: 2015-10-31
How to Cite
1.
N. S, Santhi T, T. U. Comparative study of the effect of obesity on lipid profiles levels, insulin resistance and oxidative stress in adolescents. Int J Med Res Rev [Internet]. 2015Oct.31 [cited 2024Nov.22];3(9):919-24. Available from: https://ijmrr.medresearch.in/index.php/ijmrr/article/view/345
Section
Original Article
OAI - Open Archives Initiative
