Alterations in lipid profile in gestational diabetes mellitus (GDM) and type 2 DM women during pregnancy
Keywords:
Gestational Diabetes Mellitus, Total Cholesterol(TC), Triglycerides(TGL), VLDL(Very Low Density Lipoprotein), LDL(Low Density Lipoprotein), HDL(High Density Lipoprotein)
Abstract
Objective: To study the effect of gestational diabetes mellitus (GDM) and type 2 diabetes mellitus (DM) on indices of lipid profile in maternal blood samples and compare them with normal pregnancies.
Methodology: Blood samples were collected from 45 normal pregnant women and 30 women with GDM and 15 women with type 2 DM during pregnancy. Serum lipids which include Total Cholesterol, Triglycerides, Very Low Density Lipoprotein, Low Density Lipoproteinand High Density Lipoprotein were estimated using semi-automated clinical chemistry analyzer.
Results: The results of the lipid profile showed elevated levels of Total Cholesterol, Triglycerides, Very Low Density Lipoprotein and Low Density Lipoprotein in women with GDM and pregnant type 2 DM women compared to controls. On the other hand,the High Density Lipoprotein levels were significantly elevated in controls.
Conclusion: In Gestational Diabetes Mellitus and type 2 DM during pregnancy, the lipid profile alters in such manner that could be atherogenic and possibly harmful to the fetus.
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References
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2. Freinkel N. Banting Lecture 1980. Ofpregnancy and progeny. Diabetes. 1980 Dec;29(12):1023-35. [PubMed]
3. Silverman BL, Landsberg L, Metzger BE. Fetal hyperinsulinism in offspring of diabetic mothers. Association with the subsequent development of childhood obesity. Ann N Y Acad Sci. 1993 Oct 29;699:36-45.
4. Weiss PA, Scholz HS, Haas J, Tamussino KF, Seissler J, Borkenstein MH. Long-term follow-up of infants of mothers with type 1 diabetes: evidence for hereditary and nonhereditary transmission of diabetes and precursors.Diabetes Care. 2000 Jul;23(7):905-11.
5. Silverman BL, Metzger BE, Cho NH, Loeb CA. Impaired glucose tolerance in adolescent offspring of diabetic mothers. Relationship to fetal hyperinsulinism.Diabetes Care. 1995 May;18(5):611-17. [PubMed]
6. Garber AJ. Vascular disease and lipids in diabetics.Med Clin North Am. 1998 Jul;82(4):931-48. [PubMed]
7. Gillmer, M. Diabetes in pregnancy, In: Oxford textbook of internal medicine. (1996). (3 ed., Vol. 02). Oxford University Press.
8. Kitajima M, Oka S, Yasuhi I, Fukuda M, Rii Y, Ishimaru T. Maternal serum triglyceride at 24--32 weeks' gestation and newborn weight in nondiabetic women with positive diabetic screens. Obstet Gynecol. 2001 May;97(5 Pt 1):776-80.
9. WasserstrumN. Maternal Physiology, In: Essentials of obstetrics and gynaecology, 2nded, USA, WB Saunders Company, 1995;pp.61-73.
10. Gokcel A, Bagis T, Killicadag EB, Tarim E, Guvener N. Comparison of the criteria forgestational diabetes mellitus by NDDG and Carpenter and Coustan, and the outcomes of pregnancy. J Endocrinol Invest. 2002 Apr;25(4):357-61.
11. Allain CC, Poon LS, Chan CS, Richmond W, Fu PC. Enzymatic determination of total serum cholesterol. Clin Chem. 1974 Apr;20(4):470-75. [PubMed]
12. Bucolo G, David H. Quantitative determination of serum triglycerides by the use of enzymes. Clin Chem. 1973 May;19(5):476-82. [PubMed]
13. Burstein M, Scholnick HR, Morfin R. Rapid method for the isolation oflipoproteins from human serum by precipitation with polyamines.Journal of Lipid Research. 1970 Nov;11(6):583-95.
14. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972 Jun;18(6):499-503. [PubMed]
15. Knopp RH, Van Allen MI, McNeely M, Walden CE, Plovie B, Shiota K, Brown Z. Effect of insulin-dependent diabetes on plasma lipoproteins in diabetic pregnancy.J Reprod Med. 1993 Sep;38(9):703-10. [PubMed]
16. Schaefer-Graf UM, Pawliczak J, Passow D, Hartmann R, Rossi R, Bührer C, Harder T, Plagemann A, Vetter K, Kordonouri O.Birth weight and parental BMI predict overweight in children from mothers with gestational diabetes. [PubMed]
17. Schaefer-Graf UM, Graf K, Kulbacka I, Kjos SL, Dudenhausen J, Vetter K, Herrera E. Maternal lipids as strong determinants of fetal environment and growth in pregnancies with gestational diabetes mellitus.Diabetes Care. 2008 Sep;31(9):1858-63.
18. Lasunción MA, Pallardo LF, Herrera E. Longitudinal study of plasma lipoproteins and hormones during pregnancy in normal and diabetic women. Diabetes. 1992 Dec;41(12):1651-59. [PubMed]
19. Sobki SH, Al-Senaidy AM, Al-Shammari TA, Inam SS, Al-Gwiser AA, Bukhari SA. Impact of gestational diabetes on lipid profiling and indices of oxidative stress in maternal and cord plasma. Saudi Med J. 2004 Jul;25(7):876-80. [PubMed]
20. Schaefer-Graf UM, Graf K, Kulbacka I, Kjos SL, Dudenhausen J, Vetter K, Herrera E. Maternal lipids as strong determinants of fetal environment and growth in pregnancies with gestational diabetes mellitus. Diabetes Care. 2008 Sep;31(9):1858-63.
21. Mazurkiewicz JC, Watts GF, Warburton FG, Slavin BM, Lowy C, Koukkou E. Serum lipids, lipoproteins and apolipoproteins in pregnant non-diabetic patients. J Clin Pathol. 1994 Aug;47(8):728-31.
CITATION
DOI: 10.17511/ijmrr.2015.i8.150
Published: 2015-09-30
How to Cite
1.
K. V. Alterations in lipid profile in gestational diabetes mellitus (GDM) and type 2 DM women during pregnancy. Int J Med Res Rev [Internet]. 2015Sep.30 [cited 2024Nov.8];3(8):800-4. Available from: https://ijmrr.medresearch.in/index.php/ijmrr/article/view/325
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Original Article
OAI - Open Archives Initiative
