Clinicopathological study of 50 cases of Dengue
Abstract
Aim and objective: The objective of this study was to correlate laboratory tests during the evolution of dengue fever, comparing frequencies between the different clinical forms in order to use test results to predict the severity of the disease.
Methods: This is an observational, descriptive and retrospective study of 50 patients with clinical and serological diagnoses of dengue fever. The tests analyzed were blood count, platelet count, and serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) concentrations.
Results: Thrombocytopenia and elevated transaminases were observed in patients with classic dengue fever. The main laboratory abnormalities found in dengue hemorrhagic fever were thrombocytopenia, hemoconcentration and elevated transaminases, similar to severe dengue with the exception of hemoconcentration. Most laboratory abnormalities started on the 3rd day but were more evident on the 5th day with restoration of values by the 11th day; this was more prominent in under 15-year-olds and with the more severe clinical forms.
Conclusion: These results are relevant in assessing the disease because they can be used as markers for more severe forms and can help by enabling the adaptation of the therapeutic conduct to the needs of individual patients.
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References
2. Monath TP. Dengue: the risk to developed and developing countries. Proc Natl Acad Sci U S A. 1994 Mar 29;91(7):2395-400. [PubMed]
3. Lee VJ, Lye DC, Sun Y, Fernandez G, Ong A, Leo YS. Predictive value of simple clinical and laboratory variables for dengue hemorrhagic fever in adults. J Clin Virol. 2008 May;42(1):34-9. doi: 10.1016/j.jcv.2007.12.017. Epub 2008 Feb 20. [PubMed]
4. Gubler DJ. Dengue and dengue hemorrhagic fever. Clin Microbiol Rev. 1998 Jul;11(3):480-96. [PubMed]
5. Gubler DJ, Meltzer M. Impact of dengue/dengue hemorrhagic fever on the developing world. Adv Virus Res. 1999;53:35-70. [PubMed]
6. Ageep AK, Malik AA, Elkarsani MS. Clinical presentations and laboratory findings in suspected cases of dengue virus. Saudi Med J. 2006 Nov;27(11):1711-3. [PubMed]
7. Guzmán MG, Kourí G. Dengue: an update. Lancet Infect Dis. 2002 Jan;2(1):33-42. [PubMed]
8. Gibbons RV, Vaughn DW. Dengue: an escalating problem. BMJ. 2002 Jun 29;324(7353):1563-6. [PubMed]
9. Gubler DJ. The global pandemic of dengue/dengue haemorrhagic fever: current status and prospects for the future. Ann Acad Med Singapore. 1998 Mar;27(2):227-34. [PubMed]
10. Hober D, Nguyen TL, Shen L, et al. Tumor necrosis factor alpha levels in plasma and whole- blood culture in dengue infected patients: relationship between virus detection and pre- existing specific antibodies. J Med Virol 1998; 54:210-8. [PubMed]
11. Guzmán MG, Alvarez M, Rodríguez R, Rosario D, Vázquez S, Vald s L, Cabrera MV, Kourí G. Fatal dengue hemorrhagic fever in Cuba, 1997. Int J Infect Dis. 1999 Spring;3(3):130-5. [PubMed]
12. Waterman SH, Gubler DJ. Dengue fever. Clin Dermatol. 1989 Jan-Mar;7(1):117-22. [PubMed]
13. Pervin M., Tabassum S, Ali M, Kazi M. Dengue Bulletin 2004; 28.
14. Ratageri VH, Shepur TA, Wari PK, Chavan SC, Mujahid IB, Yergolkar PN. Clinical profile and outcome of Dengue fever cases. Indian J Pediatr. 2005 Aug;72(8):705-6.
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