Study of clinical and epidemiological profile of thyroid swelling

  • Dr Chandrashekhar Srivastava Assistant Professor, Depatment of Medicine, Major S D Singh Medical college, Fatehgarh, UP, India
  • Dr Anand Saxena Associate Professor, Department of Surgery, L N Medical College, Bhopal, MP, India
Keywords: Thyroid swelling, Thyrood Adenoma, Thyroid tumour, Fine Needle Aspiration Cytology

Abstract

Introduction: Thyroid swelling remains a problem of enormous magnitude all over the world. The problem in clinical practice is to distinguish reliably the few malignant tumors from the many harmless nodules so that a definitive preoperative tissue diagnosis of the malignancy allows planning of appropriate surgery and relevant patient counseling. FNAC is reliable, safe and accurate method as a first line of evaluation in thyroid swelling before the surgery.

Material And Methods : The present study was conducted in Department of Medical College. It included Cross sectional study of cytomorphology of fine needle aspiration cytology material of 156 patients presenting with thyroid nodule in the Department. Information about the clinical presentation, treatment modality and presence or absence of malignancy was collected in a proforma and was analyzed. Statistical tests employed are tests of proportion, tests of percentage, Student’s t-test and Fisher’s exact test.

Results : The commonest age group affected was 51-60 yrs. The female patients (69.8%) outnumbered the male patients (30.1%). The cytomorphological analysis of 156 patients revealed 10 cases of neoplastic lesions. Maximum number (122) of patients was suffering with goiter followed by lymphocytic thyroiditis (12) and nodular disease (8). Amongst the malignant cases six cases were of papillary carcinoma and six cases of follicular carcinoma.

Conclusion : FNAC is a simple, safe and cost-effective diagnostic modality in the investigation of thyroid disease with high specificity and accuracy. We concluded that FNAC diagnosis of malignancy is highly significant. A benign FNAC diagnosis should be viewed with caution as false negative results do occur and these patients should be followed up and any clinical suspicion of malignancy even in the presence of benign FNAC requires surgery. So, final diagnosis and treatment pattern should be based upon histopathology.

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References

1. Burch HB, Burman KD, Reed HI, Buckner L, Raber T, Ownbey Jl. Fine needle aspiration of thyroid nodules. Determinants of insufficiency rate and malignancy yield at thyroidectomy. Acta Cytol. 1996 Nov-Dec;40(6):1176-83.

2. Gharib H, Goellner JR. Fine-needle aspiration biopsy of the thyroid: an appraisal. Ann Intern Med. 1993 Feb 15;118(4):282-9.

3. Devi , Aziz . Cytomorphological Evaluation And Thyroid Function Test (Tft) Analysis In Various Thyroid Diseases “Our Experience At Tertiary Care
CenterInternational Journal of Medical Science and Clinical Inventions Volume 1 issue 8 2014 page no. 387-392 ISSN: 2348-991X.

4. Mehdi S,Vsenwala S, Zheer M, Vasenwala A. Role of FNAC and antithyroid antibodies in the diagnosis of thyroid disorders. Indian J Pathol Microbiol. 2003 Apr;46(2):184-90.

5. Monoj Gupta ,Savita Gupta, and Ved Bhushan Gupta.”Correlation of Fine Needle aspiration Cytology with Histopathology in the Diagnosis of Solitary Thyroid Nodule”.Journal of Thyroid Research Volume 2010,Article ID 379051,5 pages doi:10.4061/2010/379051

6. Sukant Garg ,Uma Handa, Harsh Mohan, Nitin Nagarkar. Role of fine needle aspiration cytology in diagnosis and management of thyroid lesions: A study on 434 patients. Journal of Cytology.2008;25(1):13-17.

7. Franklyn JA, Sheppard MC. The value of imaging in the diagnosis of thyroid cancer. Nucl Med Commun. 1992 Sep;13(9):641-3.

8. Leonard N, Melcher DH. To operate or not to operate? The value of fine needleaspiration cytology in assessment of thyroid swelling . J Clin Pathol. 1997 Nov;50(11):941-3.

9. A. Bhatia, A .Rajwanshi, R.J. Dash, B.R. Mittal and A. K Saxena, “Lymphocytic Thyroiditis- is cytological grading significant? A correlation of grade with clinical,
biochemical, Ultrasonographic and radionuclide parameters, ”CytoJournal, vol.4, article 10,2007

10. Neelam Sood and Jitendra Singh Nigam . “Correlation of Fine Needle Aspiration Cytology Findings with Thyroid Function Test in Cases of Lymphocytic Thyroiditis”. Journal of Thyroid Research Volume 2014,Article ID 430510,5pages.http://dx.doi.org/10.1155/2014/43051014.

11. B.N. Gayathri, R Kalyani, M.L Harendra Kumar, and K Krishna Prasad, “Fine needle aspiration cytology of Hashimoto’s thyroiditis –a diagnostic pitfall with review of literature,” Journal of Cytology, vol.28 no.4,pp 210-213, 2011. Available on http://www.ncbi.nlm.nih.gov/

12. Htwe T T, Hamdi M M, Swethadri G K, Wong J O L, Soe M M, Abdullah M S; Incidence of thyroid malignancy among goitrous thyroid lesions from the Sarawak General Hospital 2000–2004. Singapore Med J. 2009 Jul;50(7):724-8.

13. Tabaqchali MA et al. Thyroid aspiration cytology in Newcastle. Ann R Coll Surg Engl. 2000 May;82(3):149-55.

14. Leonard N, Melcher DH. To operate or not to operate? The value of fine needleaspiration cytology in assessment of thyroid swelling .Jc Clin pathol 1997;941-943. Available on http://www.ncbi.nlm.nih.gov/

15. B. Mundasas, I. Macllister, J. Carson, P. C. Pyper. Accuracy of fine needle aspiration cytology in diagnosis of thyroid swellings.The Internet Journal of Endocrinology, 2006; Vol. 2; Mo. 2.

16. H. A. Nggada, A. B. Musa, B. M. Gali & M. I. Khalil : Fine Needle Aspiration Cytology Of Thyroid Nodule(S): A Nigerian Tertiary Hospital Experience . The Internet Journal ofPathology.2006 Volume 5 Number 1.avilable on www.scirp.org/journal

17.TKamra , Agarwal R et al. Evaluation Profile of Thyroid Nodule by Fnac in the Rural Population of Khanpur Kalan, Sonepat, Haryana. Journal of Clinical and Diagnostic Research. 2014 Oct, Vol-8(10): FC16- FC18. DOI: 10.7860/JCDR/2014/9134.4977

18. Vyas.C, Vijayvargiya S.A study of thyroid swelling with clinicopathological parameters. Int J Biol Med Res. 2013; 4(2) : 3250 – 3252.avilable on www.biomedscidirect.com

19. Parikh UR, Goswami HM. Fine Needle Aspiration Cytology (FNAC) Study of Thyroid Lesions GUJARAT MEDICAL JOURNAL / AUGUST-GMJ 26 2012 Vol.67 No.2 available on medind.nic.in.

20. Borgohain1 R, Lal R et al A Study of Cyto-Histological Correlation in the Diagnosis of Thyroid Swelling. IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) e-ISSN: 2279-0853, p-ISSN: 2279- 0861.Volume 13, Issue 11 Ver. IV (Nov. 2014), PP 46-49 www.iosrjournals.org

21. Rout K , Ray CS, Behera SK, Biswal R. Comparative Study of FNAC and Histopathology of Thyroid SwellingsIndian J Otolaryngol Head Neck Surg. 2011 Oct; 63(4): 370–372. doi: 10.1007/s12070-011-0280-0

22. Bhansali SK. Fine needle aspiration versus frozen section diagnosis. Arch Otolaryngol Head Neck Surg.1982;112:867–869.
CITATION
DOI: 10.17511/ijmrr.2015.i8.147
Published: 2015-09-30
How to Cite
1.
Srivastava C, Saxena A. Study of clinical and epidemiological profile of thyroid swelling. Int J Med Res Rev [Internet]. 2015Sep.30 [cited 2024Jun.21];3(8):783-8. Available from: https://ijmrr.medresearch.in/index.php/ijmrr/article/view/322
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