Tinidazole-Induced Fixed Drug Eruption: A Case Report
Keywords:
Fixed Drug Eruption, Tinidazole, Nitroimidazoles
Abstract
FDE is characterized by onset of oval or round erythematous macule on the mucosa or skin. Patients may have itching and burning sensation. 22 years old married female presented with complaining of burning sensation and ulceration in lower lip and erythematous well-defined macule on muco-cutaneous junction of vagina for last two days following intake of Tinidazole 400 mg twice daily for 1 day. FDE though not fatal, can cause cosmetic disfigurement. Fixed drug eruption in genital region is a matter of apprehension. The exact mechanism of FDE is unknown.
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References
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11. Bansal A, Kumari R, Ramam M. Fixed drug eruption due to cross reaction between two azoles used for different indications. Indian J DermatolVenereolLeprol; 2008; 74:81. [PubMed]
12. Mishra D, Mobashir M and Zaheer MS. Fixed Drug Eruption and Cross-reactivity Between Tinidazole and Metronidazole. International Journal of Dermatology; 1990; 29: 740. [PubMed]
13. Gupta R. Fixed Drug Eruption Due to Ornidazole. Indian J Dermatol. 2014 Nov-Dec; 59(6): 635. [PubMed]
14. Marya CM, Sharma G, Parashar VP, Dahiya V. Mucosal fixed drug eruption in a patient treated with ornidazole. J Dermatol Case Rep. 2012 Mar 27; 6(1):21–24. [PMC free article] [PubMed]
15. Gupta S, Jain VK, Aggarwal K, Gupta S, Mahendra A. Fixed drug eruption caused by ornidazole. Contact Dermatitis. 2005; 53:300–301. [PubMed]
16. Gupta S, Mahendra A, Gupta S, Kaur S. Multiple fixed drug eruption caused by ornidazole. Dermatitis. 2010; 21:330–333. [PubMed]
17. Sharma VK, Dhar S, Gill AN. Drug related involvement of specific sites in fixed eruptions: a statistical evaluation. J Dermatol. 1996 Aug; 23(8):530–534. [PubMed]
18. Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roborts EA. A method for estimating the probability of adverse drug reactions. ClinPharmacolTher; 1991; 30: 239-245. [PubMed]
19. Hartwig SC, Siegel J, Schneider PJ. Preventability and severity assessment in reporting adverse drug reactions. Am J Hosp Pharm; 1992; 49: 2229-32.
2. Sanmukhani J, Shah V, Baxi S, Tripathi C. Fixed drug eruption with ornidazole having cross-sensitivity to secnidazole but not to other nitro-imidazole compounds: A case report. Br J ClinPharmacol. 2010 Jun; 69(6):703–704. [PMC free article]
3. Weedon D. Skin Pathology. 2nd. London: Churchill Livingstone; 2002. The lichenoid reaction pattern (‘interface dermatitis’) pp. 42–3.
4. K Sangma, J Wahlang, M Marak, M Sangma, M Lyngdoh, D Brahma. Fixed Drug Eruption Due to Tinidazole: 2 Case Reports and Review of Literature. The Internet Journal of Pharmacology. 2012 Volume 10 Number 1. [PubMed]
5. Kanwar AJ, Sharma R, Rajgopalan M, Kaur S. Fixed drug eruption due to tinidazole with cross sensitivity to metronidazole. Dermatologica. 1990; 180(4):277. [PubMed]
6. Thami GP, Kanwar AJ. Fixed drug eruption due to metronidazole and tinidazole without cross-sensitivity to secnidazole. Dermatology; 1998; 196: 368. [PubMed]
7. Arora SK. Metronidazole causing fixed drug eruption. Indian J Dermatol Venereol Leprol; 2002; 68:108-9. [PubMed]
8. S. Gupta, K. Alam, S. Palaian, M.M. Singh, B.C. Dwari, S. Prabhu, M. Prabhu& P. Mishra: Metronidazole Induced Bullous Fixed Drug Eruptions: A Case Report And A Review Of Literature. The Internet Journal of Dermatology; 2007; Volume 5 Number 1.
9. Wahlang JB et al. Fixed drug eruption due to metronidazole: review of literature and a case report. International Journal of Pharma Sciences and Research (IJPSR); March 2012; 3(3): 331-334. [PubMed]
10. Jafferany M, Haroon TS. Tinidazole-induced fixed drug eruption. Int J Dermatol; 1988; 27:279. [PubMed]
11. Bansal A, Kumari R, Ramam M. Fixed drug eruption due to cross reaction between two azoles used for different indications. Indian J DermatolVenereolLeprol; 2008; 74:81. [PubMed]
12. Mishra D, Mobashir M and Zaheer MS. Fixed Drug Eruption and Cross-reactivity Between Tinidazole and Metronidazole. International Journal of Dermatology; 1990; 29: 740. [PubMed]
13. Gupta R. Fixed Drug Eruption Due to Ornidazole. Indian J Dermatol. 2014 Nov-Dec; 59(6): 635. [PubMed]
14. Marya CM, Sharma G, Parashar VP, Dahiya V. Mucosal fixed drug eruption in a patient treated with ornidazole. J Dermatol Case Rep. 2012 Mar 27; 6(1):21–24. [PMC free article] [PubMed]
15. Gupta S, Jain VK, Aggarwal K, Gupta S, Mahendra A. Fixed drug eruption caused by ornidazole. Contact Dermatitis. 2005; 53:300–301. [PubMed]
16. Gupta S, Mahendra A, Gupta S, Kaur S. Multiple fixed drug eruption caused by ornidazole. Dermatitis. 2010; 21:330–333. [PubMed]
17. Sharma VK, Dhar S, Gill AN. Drug related involvement of specific sites in fixed eruptions: a statistical evaluation. J Dermatol. 1996 Aug; 23(8):530–534. [PubMed]
18. Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roborts EA. A method for estimating the probability of adverse drug reactions. ClinPharmacolTher; 1991; 30: 239-245. [PubMed]
19. Hartwig SC, Siegel J, Schneider PJ. Preventability and severity assessment in reporting adverse drug reactions. Am J Hosp Pharm; 1992; 49: 2229-32.
CITATION
DOI: 10.17511/ijmrr.2015.i7.141
Published: 2015-08-31
How to Cite
1.
Kumar Sarkar M, Mishra R, Pandya P, Bansal A, Singh Bajhaiya B, Mithun M. Tinidazole-Induced Fixed Drug Eruption: A Case Report. Int J Med Res Rev [Internet]. 2015Aug.31 [cited 2024Jul.3];3(7):777-80. Available from: https://ijmrr.medresearch.in/index.php/ijmrr/article/view/320
Section
Case Report
OAI - Open Archives Initiative
