Serum total Calcium level in patients with Thalassemia
Keywords:
Calcium, Thalassemia, Iron, Hypoparathyroidism
Abstract
Introduction: Thalassemia is a genetic disorder characterized by the complete absence or reduced synthesis of α or β globin chains. The mainstay of treatment of severe β thalassemia is regular blood transfusion. Repeated blood transfusion results in hypoparathyroidism and in turn hypocalcemia due to iron overload. The aim of the study was to evaluate calcium status in thalassemia patients by estimating and comparison of serum total calcium and iron levels between normal and thalassemic patients.
Methods: The study comprised of clinically diagnosed β thalassemia Major patients and age matched controls. Results: The results revealed stastically significant decrease in serum total calcium in thalassemia patients as compared to normal while serum iron levels found to be increased indicating iron toxicity.
Discussion: On diagnosis as well as periodic assessment of thalassemia patients for hypocalcemia may be beneficial and if found calcium and vitamin D supplementation may be carried out in order to improve their bone health.
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References
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2. Thein SL. beta-Thalassemia. Baillieres Clin Haematol. 1993 Mar;6(1):151-75. [PubMed]
3. Cazzola M, De Stefano P, Ponchio L, Locatelli F, Beguin Y, Dessi C, Barella S, Cao A, Galanello R. Relationship between transfusion regimen and suppression of erythropoiesis in beta thalassemia major. Br J Haematol. 1995 Mar;89(3):473-8. [PubMed]
4. Cianciulli P."Treatment of iron overload in thalassemia". Pediatr Endocrinol Rev. 2008 Oct;6 Suppl 1:208-13. [PubMed]
5. Meropi Toumba and Nicosa Skordis. Osteoporosis syndrome in thalassemia major. J Osteoporos 2010;2010:537673. [PubMed]
6 Angelopoulos NG, Goula A, Rombopoulos G, Kaltzidou V, Katounda E, Kaltsas D, Tolis G. Hypoparathyroidism in transfusion dependent patients with β-thalassemia J Bone Miner Metab. 2006;24(2):138-45.
7. Salama OS, Al-Tonbary YA, Shahin RA, Eldeen OA. Unbalanced bone turnover in children with β- thalassemia, haematology, 2006,11(3),197-202. [PubMed]
8. Biggs H.G., Moorehead, W.R. 2-Amino-2-methyl-1-propanol as the Alkalizing Agent in an Improved Continuous-Flow Cresolphthalein Complexone Procedure for Calcium in Serum Clin Chem. 1974 Nov;20(11):1458-60. [PubMed]
9. N.W. Tietz, W.B. Saunders. Textbook of clinical chemistry.1986.
10.Artiss,Joseph D., Vinogradov S., Zak B., Spectrophotometric study of several sensitive reagents for serum iron. Clin Biochem. 1981 Dec;14(6):311-5. [PubMed]
11. N.W.Tietz. Fundamentals of clinical chemistry.1970, 658.
12.De-Sanctis V, Vullo C, Bagni B, Chiccoli L. Hyperparathyroidism in beta thalassemia major: clinical and laboratory observations in 24 patients. Acta Haematol. 1992;88(2-3):105-8. [PubMed]
13. Gabriele O. Hypoparathyroidism associated with thalassemia. South Med J. 1971 Jan;64(1):115-6. [PubMed]
14. Rombos Y, Tzanetea R, Konstantopoulos K, Simitzis S, Zervas C, Kyriaki P, Kavouklis M, Aessopos A, Sakellaropoulos N, Karagiorga M, Kalotychou V,Loukopoulos D. Chelation therapy in patients with thalassemia using the orally active iron chelators deferiprone(L1) Haematologica. 2000 Feb;85(2):115-7. [PubMed]
15. Gutteridge JM, Halliwell B. Iron toxicity and oxygen radicals. In: Hershko C, editor. Iron chelating therapy. London: Baillière Tindall, 1989:195-256.
16. Iancu T. Ultrastructural pathology of iron overload with special reference to endocrine glands. In: Pintor C, Corda R, De-Sanctis V, editors. Workshop on endocrine problems in thalassemia. Venezia: San Marco Scientific Publications, 1990:19-28.
17. Aleem A, AL-Momen AK, Al-Harakati MS, Hassan A, Al-Fawaz I. Hypocalcemia due to hypoparathyroidism in b-thalassemia major patients. Ann Saudi Med 2000;20(5-6):364-366. [PubMed]
18. Autio KA, Mait JE, Lesser M, Giardina PJ. Low bone mineral density in adolescents with β-thalassemia. J NY Acad Sci. 2005;1054:462. [PubMed]
19. Zamboni G, Marradi P, Tagliaro F, Dorizzi R, Tato L. Parathyroid hormone, calcitonin and vitamin D metabolites in beta-thalassemia major. Euro J Pediatr. 1986;145:133–136. [PubMed]
20. Goyal M, Abrol P, Lal H. Parathyroid and Calcium Status in Patients with Thalassemia, Ind J Clin Biochem. 2010; 25(4):385–387. [PubMed]
21. Dhouib N, Turki Z, Mellouli F, Ouederni M, Yahiaoui S, Nagi S, Kouki R, Ben Slama C, Bejaoui M. Hypocalcaemia due to hypoparathyroidism in β-thalassemia major. A study of a new case. Tunis Med. 2011 Mar;89(3):302-4. [PubMed]
22. Napoli N, En Carmina, Bucchieri S, Sferrazza C, Rini GB, Difede G. Low serum levels of 25-hydroxy vitamin D in adults with thalassemia major or intermedia. Bone.2006;38:888–892.
CITATION
DOI: 10.17511/ijmrr.2013.i04.08
Published: 2013-10-31
How to Cite
1.
Bandebuche S, Sagar V, Sontekke A. Serum total Calcium level in patients with Thalassemia. Int J Med Res Rev [Internet]. 2013Oct.31 [cited 2024Nov.22];1(4):190-4. Available from: https://ijmrr.medresearch.in/index.php/ijmrr/article/view/32
Section
Original Article
OAI - Open Archives Initiative
