Study of Serum Magnesium Levels in Type 2 Diabetics
Abstract
Introduction: A prospective case control study of serum magnesium levels in relations with micro & macro vascular complications of type 2 diabetes mellitus in J.L.N Hospital Ajmer.
Methods: 25 patients of type 2 diabetes mellitus admitted to J.L.N Hospital were included in the study. Also 25 non diabetic patients admitted at the same time were included in the study under the control group.
Results: The present study had diabetic patients ranging from 40-80 years. The mean serum magnesium levels were 1.68 mg/dl and 2.02 mg/dl in cases and controls respectively. The mean serum magnesium levels in patients on insulin, OHAs and on OHAs plus insulin were 1.43 mg/dl, 2.14 mg/dl and 1.53 mg/dl respectively. The mean serum magnesium levels in patients with controlled diabetes were 2mg/dl and 1.33 mg/dl in patients with uncontrolled diabetes. The mean serum magnesium levels in patients with and without diabetic retinopathy were 1.44 mg/dl and 2.11 mg/dl respectively. Whereas the mean serum magnesium levels in patients with diabetic nephropathy were 1.31 mg/dl and 2.08 mg/dl in those without nephropathy.
Conclusion: Hypomagnesemia is a factor in type 2 diabetes and associated with various complications and duration of diabetes leading to various complications. Hence it is worth measuring serum magnesium levels in patients with type 2 DM and probably correlates their relationship with various complications.
Downloads
References
2. Nadler JL, Buchanan T, Natarajan R, Antonipillai I, Bergman R & Rude RMagnesium deficiency produces insulin resistance and increased thromboxane Synthesis. Hypertension 1993 Jun;21(6 Pt 2):1024-9.
3. Sasaki S, Oshima T, Mtsuura H, et al. Abnormal magnesium status in patients with cardiovascular diseases. Clin Sci (Lond). 2000 Feb;98(2):175-81. [PubMed]
4. Nadler JL & Rude RK. Disorders of magnesium metabolism. Endocrinol Metab Clin North Am. 1995 Sep;24(3):623-41. [PubMed]
5. Nadler JL, Malayan S, Luong H, Shaw S, Natarajan RD & Rude RK. Intracellular free magnesium deficiency plays a key role in increased platelet reactivity in type II diabetes mellitus. Diabetes Care. 1992 Jul;15(7):835-41.
6. Ma J, Folsom AR, Melnick SL, Eckfeldt JH, Sharrett AR, Nabulsi AA, Hutchinson RG & Metcalf PA. Associations of serum and dietary magnesium with cardiovascular disease, hypertension, diabetes, insulin, and carotid arterial wall thickness: the ARIC study. Atherosclerosis Risk in Communities Study. J Clin Epidemiol. 1995 Jul;48(7):927-40.
7. Monika KW, Michael BZ, Giatgen AS, Richard FH, Low plasma magnesium in type 2 diabetes. Swiss Med Wkly. 2003 May 17;133(19-20):289-92. [PubMed]
8. Johannson G, Danielson BG, Ljunghall S & Wibell L. Evidence for a disturbed magnesium metabolism in diabetes- mellitus. Magnes Bull 1981; 2: 178-180. [PubMed]
9. Fujii S, Takemura T, Wada M, Akai T & Okuda K. Magnesium levels in plasma, erythrocyte and urine in patients with diabetes mellitus. Horm Metab Res. 1982 Mar;14(3):161-2. [PubMed]
10. McNair P, Christensen MS, Christiansen C, Madsbad S & Transbol I. Renal Hypomagnesaemia in human diabetes mellitus: its relation to glucose homeostasis. Eur J Clin Invest. 1982 Feb;12(1):81-5.
11. Sjögren A, Floren CH & Nilsson A. Magnesium, potassium and zinc deficiency in subjects with type II diabetes mellitus. Acta Med Scand. 1988;224(5):461-6. [PubMed]
12. Paolisso G, Scheen A, D’ Onfrio F, Lefebvre P. Magnesium and glucose. Diabetologia. 1990 Sep;33(9):511-4. [PubMed]
13. Definition and diagnosis of diabetes mellitus and intermediate hyperglycemia : report of a WHO/IDF consultation. 2006;1:12.
14. Ishrat K, SA Jaweed, JS Bardapukar, VP Patil. Study of magnesium, glycosylated haemoglobin and lipid profile in diabetic retinopathy. Indian J Clin Biochem. 2004 Jul;19(2):124-7. [PubMed]
15. Yajnik CS, Smith RF, Hockaday TD, Ward NI, Fasting plasma magnesium concentrations and glucose disposal in diabetes. Br Med J. 1984 April; 288(6423): 1032-34. [PubMed]
16. Jain AP, Gupta NN, Kumar A, Some metabolic facets of magnesium in diabetes mellitus. J Assoc Physicians India. 1976 Dec;24(12):827-31. [PubMed]
17. Nagase N et al. Hypertension and Serum Mg in the Patients with Diabetes and Coronary Heart Disease: Hypertens Res. 1996 Jun;19 Suppl 1:S65-8. [PubMed]
18. Dipankar Kundu et al, Serum magnesium levels in patients with diabetic Retinopathy, J Nat Sci Biol Med. 2013 Jan;4(1):113-6. [PubMed]
19. S. Prabodh et al, Status of Copper and Magnesium Levels in Diabetic Nephropathy Cases: a Case-Control Study from South India: Biol Trace Elem Res. 2011 Jul;142(1):29-35.