A study of serum magnesium level in type 2 diabetes mellitus and its significance
Abstract
Introduction: Hypomagnesaemia has been reported to occur in 25-38% of patients with Type 2 DM especially in those without good metabolic control. This present study has been undertaken to estimate serum magnesium level of patients with diabetes mellitus and to correlate between serum magnesium levels and glycemic control, duration of diabetes and its complications.
Methods and Materials: This is a prospective study done in March 2015 in Rajah Muthiah Medical College and Hospital. 132 Type 2 DM patients included in the study was estimated with serum magnesium level and compared with the age matched control group.
Results: The mean serum magnesium was 1.74+ 0.32mg/dl. Of the patients, 33(25%) had low serum magnesium levels (less than or equal to 1.5mg/dl). We observed that serum magnesium levels were lower in patients with increasing duration of diabetes. Out of the 19 patients who had hypomagnesaemia, 18 patients had HbA1c > 7 %. This correlates between hypomagnesaemia and poor glycemic control in our study.
Conclusion: Serum magnesium level was low in Type 2 DM; serum magnesium was low in patient with poor glycemic control.
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References
2. Arnaud MJ . Update on the assessment of magnesium status. Br J Nutr. 2008 Jun; 99 Suppl 3:S24-36. doi: 10.1017/S000711450800682X. [PubMed]
3. de Lordes Lima M, Cruz T, Pousada JC, Rodrigues LE, Barbosa K, Canguçu V. The effect of magnesium supplementation in increasing doses on the control of Type 2 DM. Diabetes Care. 1998 May; 21(5):682-6. [PubMed]
4. Wälti MK, Zimmermann MB, Walczyk T, Spinas GA, Hurrell RF. Measurement of magnesium absorption and retention in type 2 DM with use of stable isotopes. Am J Clin Nutr. 2003 Sep; 78(3):448-53. [PubMed]
5. Raheja BS, Kapur A, Bhoraskar A, Sathe SR, Jorgensen LN, Moorthi SR, Pendsey S, Sahay BK. Diabetes care Asia – India study: Diabetes care in India current status J Assoc Physicians India. 2001 Jul; 49:717-22. [PubMed]
6. A.G.Kulkarni ,Sachin K. Shendge, Vikramaditya shinde , Study of serum magnesium level in Type 2 Diabetes Mellitus , IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) e-ISSN: 2279-0853, p-ISSN: 2279-0861.Volume 13, Issue 4 Ver. VII. (Apr. 2014), PP 115-119.
7. Mohamed Murtuza Kauser, Asfia Afreen , Prabhakar K, Vageesh Kumar S R and Dinesh Javarappa, Study of serum magnesium in type 2 Diabetes Mellitus and its correlation with the modality of treatment- A south Indian study, International Journal of Biomedical And Advance Research, SSN: 2229-3809 (Online) Journal DOI:10.7439/ijbar.
8. Maj, Folsom AR, Melnick SL, Eckfeldt JH, Sharrett AR, Nabulsi AA, Hutchinson RG, Metcalf PA. Serum magnesium and dietary magnesium associated with cardiovascular disease, hypertension, diabetes, insulin and carotid arterial wall thickness; the ARJC study. J Clin Epidemiol. 1995 Jul; 48(7):927-40.
9. Paolisso G1, Sgambato S, Pizza G, Passariello N, Varricchio M, D'Onofrio F. Improved insulin response and action by chronic magnesium administration in aged NIIDM subjects. Diabetes Care. 1989 Apr; 12(4):265-9.
10. Djurhuus MS. New data of mechanisms of hypermagnesuria in type 1 diabetes mellitus. Magnes Res. 2001 Sep; 14(3):217-23. [PubMed]
11. AH Zagar, NA Shah, SR Masoodi, BA Laway et al. Copper, Zinc, and magnesium levels in non-insulin dependent diabetes mellitus. Post graduate medical journal 1998; 74: 665-668. [PubMed]
12. S.Ramadas, sharbari basu, A.R.Srinivasan, serum magnesium levels as an indicator of status of diabetes mellitus type 2, Diabetes and metabolic syndrome: clinical research and reviews; volume 9, issue 1 January-march 2015 page 42-45.
13.Sharma A, Dabla S, Agrawal RP, Barjatya H, Kochar DK, Kothari RP, serum magnesium: an early predictor of course and complications of diabetes mellitus: J Indian med assoc 2007 jan:105(1): 16,18,20. [PubMed]
14. Walti MK, Zimmermann MB, Spinas GA, Hurrell RF. Low plasma magnesium in Type 2 diabetes. Swiss Med Wkly. 2003 May 17; 133(19-20):289-92. [PubMed]
15. Mohan V, Shanthirini CS, Deepa M. Chennai urban population study-16. Diabesis Res Clin pract.1998 Sep; 34(1): 29-36.
16. Martha Rodriguez-Moran, Fernando Guerrero-Romero. Low serum magnesium levels and foot ulcers in subjects with type 2 diabetes. Arch Med Res. 2001 Jul – Aug; 32(4): 300-3. [PubMed]
17. Nadler JL, Malayan S, Luong H, Shaw S, Natarajan RD, Rude RK. Intracellular free magnesium deficiency plays a key role in decreased reactivity in type 2 diabetes mellitus. Diabetes Care. 1992 Jul; 15(7):835-41. [PubMed]
18. Guerrero-Romero F, Rodríguez-Morán M. low serum magnesium levels and metabolic syndrome. Acta Diabetol. 2002 Dec; 39(4):209-13. [PubMed]
19. Lipinski B, Lipinska L. Effect of magnesium on fibrin formation from lower molecular weight (LMV) fibrinogen. Magnes Res. 2000 Dec; 13(4):233-7.