AML presenting as bilateral proptosis with lacrimal glands involvement in a young male
Keywords:
Acute Myeloid Leukemia, Proptosis, Lacrimal Glands, Papilloedema, Chemotherapy
Abstract
Acute Myeloid Leukemia (AML) is associated with acquired genetic alterations that result in the replacement of normal marrow elements by relatively undifferentiated blast cells exhibiting one or more types of early myeloid differentiation. Bilateral proptosis with involvement of lacrimal glands and papilledema due to acute myeloid leukemia is presented in this case report. Investigations like complete blood count, peripheral blood film along with bone marrow examination helps in reaching the diagnosis early and a timely intervention thereby increasing the survival chances in such patients.
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References
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2. Chen E, Morrison DG, Donahue SP. Acute myeloid leukemia presenting as bilateral proptosis from diffuse extraocular muscle infiltration. Am J Ophthalmol. 2004 May;137(5):948-50.
3. Stein-Wexler R, Wotton-Gorges SL, West DC. Orbital granulocytic sarcoma: an unusual presentation of acute myelocytic leukemia. Pediatr Radiol. 2003 Feb;33(2):136-9. Epub 2002 Nov 12. [PubMed]
4. Stockl FA, Dolmetsch AM, Saornil MA, Font RL, Burnier MN. Jr. Orbital granulocytic sarcoma. Br J Ophthalmol. 1997 Dec;81(12):1084-8. [PubMed]
5. Jha BK, Lamba PA. Proptosis as a manifestation of acute myeloid leukaemia. Br J Ophthalmol. 1971 Dec;55(12):844-7. [PubMed]
6. Puri P, Grover AK. Granulocytic sarcoma of orbit preceding acute myeloid leukemia: a case report. Eur J Cancer Care (Engl). 1999 Jun;8(2):113-5. [PubMed]
7. Swami G, Arya A, Chowdhry B. Acute myeloid leukemia presenting with sudden bilateral proptosis as sole manifestation. Indian Pediatr. 2001 Oct;38(10):1199-200.
8. Zimmerman LE, Font RL. Ophthalmic manifestations of granulocytic sarcoma (myeloid sarcoma or chloroma) Am J Ophthalmol. 1975 Dec;80(6):975-90. [PubMed]
9. Sethi A, Ghose S, Gujral S, Jain P, Kumar R. Childhood proptosis: The invaluable but overlooked peripheral blood smear. Indian J Ophthalmol. 2001 Jun;49(2):121-3. [PubMed]
10. Davis JL, Park DW II, Font RL. Granulocytic sarcoma of the orbit: A histopathologic study. Ophthalmology. 1985 Dec;92(12):1758-62. [PubMed]
11. Rajput D1, Naval R, Yadav K, Tungaria A, Behari S. Bilateral proptosis and bitemporal swelling: A rare manifestation of acute myeloid leukemia. J Pediatr Neurosci. 2010 Jan;5(1):68-71. doi: 10.4103/1817-1745.66687. [PubMed]
12. Goldberg L, Tao A, Romano P. Severe exophthalmos secondary to orbital myopathy not due to Graves disease. Br J Ophthalmol. 1982 Jun;66(6):392-5. [PubMed]
13. Consul BN, Kulshrestha OP, Mehrotra AS. Bilateral proptosis in acute myeloid leukaemia. Br J Ophthalmol. 1967 Jan;51(1):65-7. [PubMed]
14. Panda A, Dayal Y: Acute proptosis in myeloid leukaemia. Indian J Ophthalmol. 1984 Jul-Aug;32(4):239-41.
CITATION
DOI: 10.17511/ijmrr.2015.i6.124
Published: 2015-07-31
How to Cite
1.
Wani RM, Rashid S, Mir AM, Suraya S. AML presenting as bilateral proptosis with lacrimal glands involvement in a young male. Int J Med Res Rev [Internet]. 2015Jul.31 [cited 2024Apr.29];3(6):669-72. Available from: https://ijmrr.medresearch.in/index.php/ijmrr/article/view/300
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Section
Case Report
OAI - Open Archives Initiative
