Clinico-epidemiological profile of patients with microbial keratitis in Kashmir valley

  • Dr Tufela Shafi (MS), GB Pant Pediatric Department of Ophthalmology, Government Medical College, Srinagar, (Kashmir), India
  • Dr Raashid Maqbool Wani (MS), Department of Ophthalmology, Government Medical College, Srinagar, (Kashmir), India
  • Dr Tasneem Muzaffar (MS), SKIMS, Srinagar (Kashmir), India
  • Dr Mehmooda Ashai (MS), Retired Professor at Department of Ophthalmology, Government Medical College, Srinagar (Kashmir), India
  • Dr Saqib Suraya (MBBS), Department of Ophthalmology, Government Medical College, Srinagar, (Kashmir), India
Keywords: Bacterial Keratitis, Fungal Keratitis, Antibiotic Sensitivity

Abstract

Purpose: This study was undertaken to provide information on the clinico-epidemiological profile of patients clinically suspected with bacterial and fungal keratitis, who were admitted in the Ophthalmology unit of a tertiary center during a 2 year period.

Methods: This is a prospective study of all the patients who were admitted in the eye ward of Government Medical College Srinagar (India) between September 2010 and September 2012. 100 patients of bacterial and fungal corneal keratitis without any history of preexisting ocular or systemic disease were included in the study. All patients were assessed, admitted and completely evaluated in hospital and managed accordingly. Corneal ulcer scrapings were taken at presentation, at the Department of Microbiology.

Results: Maximum numbers of patients among males (61.90%) were agricultural workers and among females, 81.08% were housewives. It was seen that majority of patients (79%) presented within 1st week of onset of symptoms and among them growth was seen in 64.6%. Growth was seen in 32cases (72.72%) out of 44 cases who gave a history of trauma whereas growth was seen in 36 cases (64.28%) who did not give a clear history of trauma.

Conclusion: Bacterial and fungal keratitis in Kashmir is more prevalent in rural areas, with men being more at risk of developing the disease. There is a seasonal variation in the incidence of the disease; higher cases being reported during the harvesting season. Trauma with organic or vegetable matter is a common preceding factor. Microbiological studies should preferably be carried out in all cases.

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References

1. National Programme for Control of Blindness. Report of National Programme for Control of Blindness, India and World Health Organization. 1986-89.

2. Dandona R, Dandona L. Corneal blindness in a southern Indian population: Need for health promotion strategies. Br J Ophthalmol. 2003 Feb;87(2):133-41. [PubMed]

3. JN Rohatgi. Bacteriology of corneal ulcer with special reference to hypopyon corneal ulcer. Ind J Ophthalmol 1967; 15 (2):54-57. [PubMed]

4. Synder RW, Hyndiuk RA. Mechanisms of bacterial invasion of the cornea. In: Tasman W, Jaeger EA, editors. Duane‘s Foundations of Clinical Ophthalmology. Philadelphia: J B Lippincott & Co.; 1990. pp. 11–44. [PubMed]

5. Reichart R, Stern GA. Qualitative adherence of bacteria to human corneal epithelial cells. Arch Ophthalmol. 1984; 102:1394. [PubMed]

6. Panjwani N, Clerk B, Cohen M, Barza M, Baum J. Differential binding of Ps. aeruginosa and Staph. aureus to corneal epithelium in culture. Invest Ophthalmol Vis Sci. 1990; 31:696. [PubMed]

7. Stephen A. Klotz, Christopher C. Penn, Gerald J. Negvesky, Salim I. Butrus. Fungal and Parasitic Infections of the Eye. Clin Microbiol Rev. 2000 Oct; 13(4): 662–685. [PubMed]

8. Fudnawala V, Gandhi G, Soni KN, Ahir HD, Ganvit SS. Epidemiology and etiological characteristics of microbiological diagnosed cases of bacterial and fungal keratitis in Baroda, India. Delhi Journal of Ophthalmology Januray 2006; Vol 11(2) and Vol 12 (1).

9. Basak SK, Basak S, Mohanta A, Bhowmick A. Epidemiological and Microbiological Diagnosis of Suppurative Kertatitis in Gangetic West Bengal, Eastern India. Indian J Ophthalmol. 2005 Mar;53(1):17-22. [PubMed]

10. Pichare A, Patwardhan N, Damle AS, Deshmukh AB. Bacteriological and mycological study of corneal ulcers in and around Aurangabad. Indian J Pathol Microbiol, 2004 Apr; 47(2): 284-6. [PubMed]

11. Laspina F, Samudio M, Ciblis D, Ta CN, Farina N, Klauss R Sanabria V, H Mino de Kaspar. Epidemiological characteristics of microbiological results on patients with infectious corneal ulcers: a 13 year survey in Paraguay. Graefes Arch Clin Exp Ophthalmol 2004 Mar; 242 (3): 204-9. [PubMed]

12. Bourcier T, Thomas F, Borderie V, Chaumeil C, Laroche L; Bacterial Keratitis: Predisposing factors, clinical and microbiological review of 300 cases. Br J Opthalmol 2003 Jul; 87: 834-838. [PubMed]

13. Tanure Ma, Cohen EJ, Sudesh S, Rapuano CJ, Laibson PR. Spectrum of fungal keratitis at Wills Eye Hospital, Philadelphia, Pennsylvania. Cornea 2000 May; 19 (3): 307-12. [PubMed]

14. Upadhyay MP, Karmacharya PC, Koirala S, Tuladhar NR, Bryan LE, Smolin G, Whitcher JP. Epidemiological characteristics, predisposing factors and etiologic diagnosis of corneal ulceration in Nepal. Am. J. Ophthalmology 1991; 111 (1): 92-9.

15. Subudhi BNR, Dash S, Desinayak N, Subudhi P. Geographical and social impact on causation and prognosis of fungal keratitis in Southern Orissa. AIOC 2005 Proceedings: 193-195.

16. Bharathi MJ, Ramakrishanan R, Vasu S, Meenakshi R, Palaniappan R. Epidemiology of bacterial keratitis in a referral centre in South India. Indian Journal of Medical Microbiology 2003; Vol 21: 239-245.

17. Chander J, A Sharma. Prevalence of fungal corneal ulcers in northern India. Infection 1994; 22 (3): 207-9. [PubMed]

18. Kotigadde S, Ballal M, Jyothirlatha, Kumar A, N Srinavasa RP, Shivananda GP. Mycotic Keratitis: A Study in coastal Karnataka. Indian journal of ophthalmology 1992; 40:31-33. [PubMed]

19. Leck AK, Thomas PA, Hagan M, Kaliamurthy J, Ackuaku E, John M, Newman MJ, Codjoe FS, Opintan JA, Kalavathy CM, Essuman V, Jesudasan CAN, Johnson GJ. Aetiology of suppurative corneal ulcers in Ghana and South India, and epidemiology of fungal keratitis. British Journal of Ophthalmology 2002; 86: 1211-1215.

20. Chowdhary A, Singh K. Spectrum of fungal keratitis in North India. Cornea 2005 March-April; 2(2): 69-76.

21. Dunlop AA, Wright ED, Howlader SA, Nazrul I, Husain R, McClellan K, Billson FA. Suppurative corneal ulceration in Bangladesh. A study of 142 cases examining the microbiological diagnosis, clinical and epidemiological features of bacterial and fungal keratitis. Aust. N Z J Ophthalmol 1994 May; 22 (2): 105-10. [PubMed]

22. Schafer F, Bruttin O, Zografos L, Guex-Crossier Yan. Bacterial keratitis: a prospective clinical and microbiological study. British Journal of Ophthalmology 2001 July; 85: 842-847. [PubMed]

23. Srinivasan M, Gonzales CA, George C, Cevallos V, Mascarenhas JM, Asokan B, Wilkins J, Smolin G, Whitcher JP. Epidemiology and etiological diagnosis of corneal ulceration in Madurai, South India. British Journal of Ophthalmology, 1997; 81 (11): 965-71.
CITATION
DOI: 10.17511/ijmrr.2015.i6.127
Published: 2015-07-31
How to Cite
1.
Shafi T, Maqbool Wani R, Muzaffar T, Ashai M, Suraya S. Clinico-epidemiological profile of patients with microbial keratitis in Kashmir valley. Int J Med Res Rev [Internet]. 2015Jul.31 [cited 2024Nov.8];3(6):641-7. Available from: https://ijmrr.medresearch.in/index.php/ijmrr/article/view/295
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Original Article