Prevalence of metabolic syndrome in Psoriasis – a case control study

  • Dr. K.V.T. Gopal Maharajah’s Institute of Medical Sciences, Nellimarla, Vizianagaram Dt., Andhra Pradesh, India
  • Dr. G. Deepika Raj Maharajah’s Institute of Medical Sciences, Nellimarla, Vizianagaram Dt., Andhra Pradesh, India
  • Dr T. Narayana Rao Department of Dermatology, Maharajah’s Institute of Medical Sciences, Nellimarla, Vizianagaram Dt., Andhra Pradesh, India
DOI: https://doi.org/10.17511/ijmrr.2015.i4.079
Keywords: Psoriasis, Metabolic Syndrome, Hyperlipidemia, Obesity

Abstract

Introduction: Recently, associations between psoriasis and metabolic disorders such as obesity, diabetes, and atherogenic dyslipidemia have been recognized. The present study was performed to know the prevalence of metabolic syndrome and its individual components in Psoriatic patients and compare them with age and sex matched controls.

Methods: The study included 60 psoriatic patients and 60 age and sex matched controls. Severity of psoriasis was assessed according to psoriasis area and severity index (PASI) score. Waist circumference, blood pressure, fasting plasma glucose, serum cholesterol, HDL, LDL, VLDL and triglycerides were recodrded in all patients and controls. Metabolic syndrome was diagnosed by the presence of three or more of the five criteria of the 2005 revised National Cholesterol Education Programme’s Adult Treatment Panel III . Statistical analysis of the data was performed.

Results: Prevalence of metabolic syndrome was seen in 20 cases (33.3%) compared to 9 (15%) controls which was statistically significant (P = 0.019). Metabolic syndrome, high fasting blood glucose, high triglyceride levels and low HDL levels were significantly more in cases than controls. There was no significant difference in the prevalence of abdominal obesity and hypertension among cases and controls.

Conclusion: There is a need for regular evaluation of psoriatic patients, even younger patients and those with mild disease, for the presence of any of the components of metabolic syndrome. Dermatologists should screen all psoriasis patients to detect the existence of comorbid conditions such as metabolic syndrome and its individual components.

Downloads

Download data is not yet available.

References

1. Gelfand JM, Weinstein R, Porter SB, Neimann AL, Berlin JA, Margolis DJ. Prevelance and treatment of psoriasis in the United Kingdom: A population-based study. Arch Dermatol. 2005Dec;141(12):1537-41. [PubMed]

2. Schon MP, Boehncke WH. Psoriasis. N Engl J Med 2005 May 5;352(18):1899-912. [PubMed]

3. Henseler T, Christophers E. Disease concomitance in psoriasis. J Am Acad Dermatol. 1995 Jun;32(6):982-6. [PubMed]

4. Rocha-Pereira P, Santos-Silva A, Rebelo I, Figueiredo A. The inflammatory response in mild and in severe psoriasis. Br J Dermatol 2004 May;150(5):917-28. [PubMed]

5. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Ecke RH, Franklin BA, et al. Diagnosis and Management of the Metabolic Syndrome. Circulation 2005 Oct 25;112(17):2735-52. [PubMed]

6. Gelfand JM, Neimann AN, Shin DB, Wang X, Margolis DJ, Troxel AB. Risk of myocardial infarction in patients with psoriasis. JAMA 2006 Oct 11;296(14):1735-41. [PubMed]

7. Cohen AD, Sherf M, Vidavsky L, Vardy DA, Shapiro J, Meyerovitch J. Association between psoriasis and the metabolic syndrome. Dermatol 2008;216(2):152-5. [PubMed]

8. Neimann AL, Shin DB, Wang X, Margolis DJ, Troxel AB, Gelfand JM. Prevalence of cardiovascular risk factors in patients with psoriasis. J Am Acad Dermatol 2006 Nov;55(5):829-35. [PubMed]

9. Alberti KG, Zimmet P, Shaw J. IDF Epidemiology Task Force Consensus Group. The metabolic syndrome: A new worldwide definition. Lancet 2005 Sep 24-30;366(9491):1059-62. [PubMed]

10. Christophers E, Mrowietz U. Psoriasis. In: Burgdorf WHC, Plewig G, Wolff HH, Landthaler M, editors. Dermatology. 3 rd ed. Heidelberg: Springer Medizine Verlag; 2009. p. 507.

11. Mallbris L, Granath F, Hamsten A, Stahle M. Psoriasis is associated with lipid abnormalities at the onset of skin disease. J Am Acad Dermatol 2006 Apr;54(4):614-21. [PubMed]

12. Sommer DM, Jenisch S, Suchan M, Christophers E, Weichental M. Increased prevalence of metabolic syndrome in patients with moderate to severe psoriasis. Arch Dermatol Res 2006 Dec;298(7):321-8. [PubMed]

13. Madanagobalane S, Anandan S. Prevalence of metabolic syndrome in South Indian patients with psoriasis vulgaris and the relation between disease severity and metabolic syndrome: A hospital-based case-control study. Indian J Dermatol 2012;57:353-7.

14. Nisa N, Qazi MA. Prevalence of metabolic syndrome in patients with psoriasis. Indian J Dermatol Venereol Leprol 2010 Nov-Dec;76(6):662-5. [PubMed]

15. Gisondi P, Tessari G, Conti S, Piaserico S, Schianchi S, Peserico A, et al. Prevalence of metabolic syndrome in patients with psoriasis: A hospital - based case - control study. Br J Dermatol 2007 Jul;157(1):68-73. [PubMed]

16. Sterry W, Strober BE, Menter A. Obesity in psoriasis: The metabolic, clinical and therapeutic implications. Report of an interdisciplinary conference and review. Br J Dermatol 2007 Oct;157(4):649-55.

17. Takahashi H, Iizuka H. Psoriasis and metabolic syndrome. J Dermatol 2012 Mar;39(3):212-8. [PubMed]

18. Alsufyani MA, Golant AK, Lebwohl M. Psoriasis and the metabolic syndrome. Dermatol Ther 2010 Mar-Apr;23(2):137-43. [PubMed]

19. Pietrzak A, Chodorowska G, Szepietowski J, Zalewska-Janowska A, Krasowska D, Hercogová J. Psoriasis and serum lipid abnormalities. Dermatol Ther 2010 Mar-Apr;23(2):160-73. [PubMed]

20. Vena GA, Vestita M, Cassano N. Psoriasis and cardiovascular disease. Dermatol Ther 2010 Mar-Apr;23(2):144-51.
CITATION
DOI: 10.17511/ijmrr.2015.i4.079
Published: 2015-05-31
How to Cite
1.
Gopal K, Raj GD, Rao TN. Prevalence of metabolic syndrome in Psoriasis – a case control study. Int J Med Res Rev [Internet]. 2015May31 [cited 2024May3];3(4):404-8. Available from: https://ijmrr.medresearch.in/index.php/ijmrr/article/view/250
Issue
Vol 3 No 4 (2015): MAY
Section
Original Article