Steven-Johnson Syndrome (SJS) in a Multiple Myeloma patient treated with lenalidomide and low dose dexamethasone regimen: a rare Case Report
Keywords:
Lenalidomide, Immunomodulatory Drugs, Multiple Myeloma, Adverse Cutaneous Reactions, Stevens-Johnson Syndrome
Abstract
Lenalidomide is an immunomodulatory drug (IMiD), a derivative of thalidomide used in the treatment of multiple myeloma. Stevens-Johnson syndrome (SJS) is a rare but life-threatening cutaneous adverse reaction, at a rate of 1.1 to 7.1 cases per million person-years, mortality rate between 1% to 3% and 10% to 70% when it is associated with TIN. Very few cases of Lenalidomide induced SJS has been reported. We describe a case of Stevens-Johnson syndrome induced by induction therapy lenalidomide-low dose Dexamethasone regimen in a 56 year-old male who underwent induction therapy for multiple myeloma.
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References
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2. Roujeau JC: Stevens-Johnson syndrome and toxic epidermal necrolysis are severity variants of the same disease which differs from erythema multiforme. J Dermatol 24(11):726-729, 1997.
3. Svigguni H, Davis M, Rajkumar V, Dispenzieri A. Dermatologicadverse effects of lenalidomide therapy for amyloidosis andmultiple myeloma. Arch Dermatol. 2006 Oct;142(10):1298-302. [PubMed]
4. Castaneda CP, Brandenburg NA, Bwire R, Burton GH, Zeldis JB. Erythema multiforme/Stevens---Johnson syndrome/toxic epi-dermal necrolysis in lenalidomide-treated patients. J Clin Oncol. 2009 Jan 1;27(1):156-7. doi: 10.1200/JCO.2008.20.3737. Epub 2008 Dec 1.
5. Allegra A, Alonci A, Penna G, Russo S, Gerace D, Greve B, et al.Stevens-Johnson syndrome after lenalidomide therapy for mul-tiple myeloma: a case report and a review of treatment options.Hematol Oncol. 2012;30:41---5.
6. Chavakis E, Dernbach E, Hermann C, Mondorf UF, Zeiher AM,Dimmeler S. Oxidized LDL inhibits vascular endothelial growthfactor-induced endothelial cell migration by an inhibitory effecton the Akt/endothelial nitric oxide synthase pathway. Circula-tion. 2001;103:2102 - 7.
CITATION
DOI: 10.17511/ijmrr.2015.i3.063
Published: 2015-04-30
How to Cite
1.
kumar Kalita L, Kalita C, Kamar Gogoi P, Ch. Sarma U. Steven-Johnson Syndrome (SJS) in a Multiple Myeloma patient treated with lenalidomide and low dose dexamethasone regimen: a rare Case Report. Int J Med Res Rev [Internet]. 2015Apr.30 [cited 2024Nov.8];3(3):353-5. Available from: https://ijmrr.medresearch.in/index.php/ijmrr/article/view/239
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Case Report