47, XYY Syndrome and its Association with Male Infertility: Case Report

  • Dr Bheem Prasad Assistant Professor, Department of Anatomy, All India Institute of Medical Sciences, Patna, Bihar, India
  • Dr. Dinesh Parmar Ph.D, Guest Faculty, Department of Biochemistry & Genetics, Barkatullah University, Bhopal, MP, India
  • Dr. Naresh Chander Sharma Ph.D, Professor & Head, Department of Biochemistry & Genetics, Barkatullah University, Bhopal, MP, India
DOI: https://doi.org/10.17511/ijmrr.2015.i2.037
Keywords: 47, XYY syndrome, Chromosomal anomaly, Genetic counselling, Male infertility, Severe oligozoospermia

Abstract

47, XYY syndrome is one of the most common sex chromosomal anomaly found in humans after Klinfelter syndrome (47, XXY). It is frequently associated with infertility in males. This syndrome has an extra Y chromosome (XYY) due to non-disjunction of the Y chromosome in paternal meiotic II. The presence of an extra Y chromosome causes hormonal disbalance in the gonads that responsible for abnormal function of human chorionic gonadotropin. In the present study two cases of infertile men with severe oligozoospermia and azoospermia that also confirm by conventional cytogenetic analysis of the peripheral blood lymphocytes revealed the constitutional karyotype of 47, XYY. This report is likely to be helpful for counselling and early management of such infertile males.

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References

1. Martin RH. Cytogenetic determinants of male fertility. Hum Reprod update. 2008; Jul-Aug: 14(4):379-90. [PubMed]

2. Geerts M, Steyaert J, Fryns JP. The XYY syndrome: a follow-up study on 38 boys Genet Couns. 2003;14(3):267-79. [PubMed]

3. Faed M, Robertson J, MacIntosh WG, Grieve J. Spermatogenesis in an infertile XYY man. Hum Genet. 1976 Aug 30;33(3):341-7. [PubMed]

4. Ratcliffe SG, Butler GE, James M. Edinburgh study of growth and development of children with sex chromosome abnormalities. In Children and Young Adults with Sex Chromosome Aneuploidy Edited by: Evans JA, Hamerton JL, Robinson A. New York: Wiley-Liss for the National Foundation-March of Dimes; 1990. P.59-115.

5. de Krester, D.M. Endocrinology of Male Infertility. Brit. Med. Bullet. 1979; 35(2):187-92. [PubMed]

6. El-Dahtoryl F, Elsheikha HM. Male infertility related to an aberrant karyotype 47, XYY: four case reports. Cases J. 2009 Jan 8;2(1):28. doi: 10.1186/1757-1626-2-28. [PubMed]

7. Ratcliffe SG, Read G, Pan H, Fear C, Lindenbaum R, Crossley J. Prenatal testosterone levels in XXY and XYY males. Horm Res. 1994;42(3):106-9. [PubMed]

8. Foresta C, Moro E, Ferlin A. Y chromosome microdeletions and alterations of spermatogenesis. Endocr Rev. 2001 Apr;22(2):226-39. [PubMed]

9. Prasad B, Jain R. The Cytogenetic basis of human infertility: a review. IOSR-JDMS. 2014: 13(8): 83-8.
CITATION
DOI: 10.17511/ijmrr.2015.i2.037
Published: 2015-03-31
How to Cite
1.
Prasad B, Parmar D, Chander Sharma N. 47, XYY Syndrome and its Association with Male Infertility: Case Report. Int J Med Res Rev [Internet]. 2015Mar.31 [cited 2024Jul.3];3(2):234-6. Available from: https://ijmrr.medresearch.in/index.php/ijmrr/article/view/216
Issue
Vol 3 No 2 (2015): MARCH
Section
Case Report