47, XYY Syndrome and its Association with Male Infertility: Case Report

  • Dr Bheem Prasad Assistant Professor, Department of Anatomy, All India Institute of Medical Sciences, Patna, Bihar, India
  • Dr. Dinesh Parmar Ph.D, Guest Faculty, Department of Biochemistry & Genetics, Barkatullah University, Bhopal, MP, India
  • Dr. Naresh Chander Sharma Ph.D, Professor & Head, Department of Biochemistry & Genetics, Barkatullah University, Bhopal, MP, India
DOI: https://doi.org/10.17511/ijmrr.2015.i2.037
Keywords: 47, XYY syndrome, Chromosomal anomaly, Genetic counselling, Male infertility, Severe oligozoospermia

Abstract

47, XYY syndrome is one of the most common sex chromosomal anomaly found in humans after Klinfelter syndrome (47, XXY). It is frequently associated with infertility in males. This syndrome has an extra Y chromosome (XYY) due to non-disjunction of the Y chromosome in paternal meiotic II. The presence of an extra Y chromosome causes hormonal disbalance in the gonads that responsible for abnormal function of human chorionic gonadotropin. In the present study two cases of infertile men with severe oligozoospermia and azoospermia that also confirm by conventional cytogenetic analysis of the peripheral blood lymphocytes revealed the constitutional karyotype of 47, XYY. This report is likely to be helpful for counselling and early management of such infertile males.

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CITATION
DOI: 10.17511/ijmrr.2015.i2.037
Published: 2015-03-31
How to Cite
1.
Prasad B, Parmar D, Chander Sharma N. 47, XYY Syndrome and its Association with Male Infertility: Case Report. Int J Med Res Rev [Internet]. 2015Mar.31 [cited 2024Nov.23];3(2):234-6. Available from: https://ijmrr.medresearch.in/index.php/ijmrr/article/view/216
Issue
Vol 3 No 2 (2015): MARCH
Section
Case Report