Comparison of HbA1c And FBS Among Diabetics And Non-diabetics to Evaluate Role of HbA1c as a Screening Tool
Keywords:
FBS, HbA1c, Type 2 Diabetes
Abstract
Background: The increase in the incidence of Diabetes in both the urban and rural sectors of population demands a proper screening strategy for early diagnosis, to delay the complications associated with this disorder.
Aim: To evaluate HbA1c as a diagnostic tool for screening purposes at the community level.
Materials and Methods: 50 Type 2 Diabetics were included as cases and 50 healthy individuals were taken as controls in this study. FBS and HbA1c were estimated in them, and the data was statistically analyzed using SPSS software version17.
Results: A significantly (p<0.001) strong and positive correlation between FBS and HbA1c with a “r” value 0.908 was observed. HbA1c showed 100% sensitivity and specificity at a best cut off value of 6.7%.
Conclusion: Hba1c can be used as an effective screening tool at the community level, provided that the test should be performed using a method that is standardized.
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References
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10) Aruna D. Pradhan, Nader Rifai, Julie E. Buring, and Paul M Ridker. HbA1c Predicts Diabetes but not Cardiovascular Disease in Non-Diabetic Women. The American Journal Of Medicine. August 2007; 120(8):720-727. [PubMed]
11) Tanaka Y, Atsumi Y, Matsuoka K, Mokubo A, Asahina T, Hosokawa K, et al. Usefulness of stable HbA(1c) for supportive marker to diagnose diabetes mellitus in Japanese subjects. Diabetes Res Clin Pract. Jul 2001;53(1):41-5. [PubMed]
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13) E. Mannucci, A. Ognibene, I. Sposato, M. Brogi, G. Gallori. Fasting plasma glucose and glycated haemoglobin in the screening of diabetes and impaired glucose tolerance. ACTA DIABETOLOGICA , December 2003; 40(4): 181-186.
14) Norberg M, Eriksson JW, Lindahl B, Andersson C, Rolandsson O, Stenlund H, et al. A combination of HbA1c, fasting glucose and BMI is effective in screening for individuals at risk of future type 2 diabetes: OGTT is not needed. J Intern Med. Sep 2006;260(3):263-71.
2) Saudek CD, Herman WH, Sacks DB, Bergenstal RM, Edelman D, Davidson MB. A new look at screening and diagnosing diabetes mellitus. J Clin Endocrinol Metab. July 2008; 93(7):2447-53. [PubMed]
3) Ginde AA, Cagliero E, Nathan DM, Camargo CA Jr. Value of risk stratification to increase the predictive validity of HbA1c in screening for undiagnosed diabetes in the US population. J Gen Intern Med. Sep 2008; 23(9):1346-53. [PubMed]
4) Deborah J, Wexler, David M. Nathan, Richard W. Grant, Susan Regan, Allison L,et al. Prevalence of Elevated Hemoglobin A1c among Patients Admitted to the Hospital without a Diagnosis of Diabetes. J Clin Endocrinol Metab. 2008; 93:4238– 4244.
5) Ghazanfari Z, Haghdoost AA, Alizadeh SM, Atapour J, Zolala F. A Comparison of HbA1c and Fasting Blood Sugar Tests in General Population. Int J Prev Med. 2010 ;1(3):187-94. [PubMed]
6) Robert A. Silverman, Raymond Pahk, Michelle Carbone, Evelyn Wells, Ron Mitzner, Katy Burris, et al. The Relationship of Plasma Glucose and HbA1c Levels among Emergency Department Patients with No Prior History of Diabetes Mellitus. Acamedic Emergency Medicine. 2006; 13:722–726. [PubMed]
7) Padala Ravi Kumar, Anil Bhansali, Muthuswamy Ravikiran, Shobhit Bhansali, Pinaki Dutta, J. S. Thakur, et al. Utility of Glycated Hemoglobin in Diagnosing Type 2 Diabetes Mellitus: A Community-Based Study. J Clin Endocrinol Metab. 2010; 95: 2832–2835.
8) SA Mostafa, K Khunti, ES Kilpatrick, D Webb, BT Srinivasan, LJ Gray and MJ Davies. Diagnostic performance of using one- or two-HbA1c cut-point strategies to detect undiagnosed type 2 diabetes and impaired glucose regulation within a multi-ethnic population. Diabetes and Vascular Disease Research. Jan 2013;10(1):84-92.
9) Rajni Dawar Mahajan , Bhawesh Mishra. Using Glycated Hemoglobin HbA1c for diagnosis of Diabetes mellitus: An Indian perspective. Int J Biol Med Res. 2011; 2(2): 508-512.
10) Aruna D. Pradhan, Nader Rifai, Julie E. Buring, and Paul M Ridker. HbA1c Predicts Diabetes but not Cardiovascular Disease in Non-Diabetic Women. The American Journal Of Medicine. August 2007; 120(8):720-727. [PubMed]
11) Tanaka Y, Atsumi Y, Matsuoka K, Mokubo A, Asahina T, Hosokawa K, et al. Usefulness of stable HbA(1c) for supportive marker to diagnose diabetes mellitus in Japanese subjects. Diabetes Res Clin Pract. Jul 2001;53(1):41-5. [PubMed]
12) Inoue K, Matsumoto M, Kobayashi Y. The combination of fasting plasma glucose and glycosylated hemoglobin predicts type 2 diabetes in Japanese workers. Diabetes Res Clin Pract. Sep 2007;77(3):451-8. [PubMed]
13) E. Mannucci, A. Ognibene, I. Sposato, M. Brogi, G. Gallori. Fasting plasma glucose and glycated haemoglobin in the screening of diabetes and impaired glucose tolerance. ACTA DIABETOLOGICA , December 2003; 40(4): 181-186.
14) Norberg M, Eriksson JW, Lindahl B, Andersson C, Rolandsson O, Stenlund H, et al. A combination of HbA1c, fasting glucose and BMI is effective in screening for individuals at risk of future type 2 diabetes: OGTT is not needed. J Intern Med. Sep 2006;260(3):263-71.
CITATION
DOI: 10.17511/ijmrr.2013.i03.08
Published: 2013-08-31
How to Cite
1.
Laxmikanth B, Ahmed Siddiqui I, Neha N. Comparison of HbA1c And FBS Among Diabetics And Non-diabetics to Evaluate Role of HbA1c as a Screening Tool. Int J Med Res Rev [Internet]. 2013Aug.31 [cited 2024Nov.8];1(3):125-30. Available from: https://ijmrr.medresearch.in/index.php/ijmrr/article/view/19
Section
Original Article
OAI - Open Archives Initiative
