The Diagnostic Efficacy of Urine Cytology in Screening Bladder Cancers: A Retrospective Study

  • Dr Vissa Shanthi MD, Associate professor, Department of Pathology, Narayana Medical College and hospital, Nellore, Andhrapradesh, India
  • Dr B.Shyam Sundara Rao M.D, Associate Professor, Department of Pathology, Narayana Medical College and hospital, Nellore, Andhrapradesh, India
  • Dr C.Nandam Mohan Rao MD, Associate professor, Department of Pathology, Narayana Medical College and hospital, Nellore, Andhrapradesh, India
  • Dr D. Bhavana Grandhi M.D, Assistant Professor, Department of Pathology, Narayana Medical College and hospital, Nellore, Andhrapradesh, India
  • Dr E.Vangala Chidananda Reddy M.D, Assistant Professor, Department of Pathology, Narayana Medical College and hospital, Nellore, Andhrapradesh, India
  • Dr F.Swathi Sreesailam M.D, Assistant Professor, Department of Pathology, Narayana Medical College and hospital, Nellore, Andhrapradesh, India
Keywords: Urine cytology, Bladder Tumors, Tumor Grade

Abstract

Background: Exfoliative urine cytology is considered to be an essential non-invasive procedure for the diagnosis of bladder cancers and also for monitoring the patients with bladder cancers.

Objective: The present study was carried out to determine the efficacy of urinary cytology in detecting the bladder cancer by analyzing the cytological findings in histopathologically proven bladder cancer patients.

Methods: Urine cytology findings in 56 patients, who were histopathologically diagnosed to have bladder cancer were analyzed retrospectively. Urine specimen was centrifuged and sediment was examined for tumor cells.

Results: Out of 56 patients studied, 28 patients showed malignant cells in urine (50%), 6 patients (10.71%) showed suspicious cells, 3 patients (5.36%) showed dysplastic cells and 19 patients (33.93%) urine cytology was negative for malignant cells. Urine cytology for malignant cells was positive in most cases having high grade bladder tumors and in tumors in advanced stage showing muscle infiltration.

Conclusion: Urinary cytology is a less expensive, non-invasive procedure used for screening bladder tumors and can detect the high grade tumors and tumors with higher staging effectively.

Downloads

Download data is not yet available.

References

1. Maximilian Burger, James W.F Catto, Guido Dalbag N, H.Barton Grossman, Harry Herr, Pierre Karkiewicz, Wassim Kassouf, Lambertus A.Kiemeney,Carlo La Vecchia, Shahrokh Shariat and Yair Lotan. Epidemiology and risk factors of Urothelial Bladder cancer.European Urology 2013;vol 63 issue1:234-241.

2. Freidell GH, Hawkins AR, Ahmed SW, Schmidt JE. The role of urinary tract cytology in the detection and clinical management of bladder cancer.In: Bonney WW,ed.AUA Monograph, Bladder Cancer vol 1. Baltimore: The Williams and Wilkins Co.,1982;49-62.

3. William M. Murphy, Mark S. Soloway, Alina F. Jukkola, William N. Crabtree and Kimball S Ford. Urinary cytology and bladder cancer. The cellular features of transitional cell neoplasms. Cancer 1984;53:1555-65. [PubMed]

4. Murphy WM, Irving CC. The cellular features of developing carcinoma in murine urinary bladder. Cancer 1981;47:514-522. [PubMed]

5. Murphy WM, Soloway MS. Developing carcinoma (dysplasia) of urinary bladder. Pathol Annu 1982;17:197-217. [PubMed]

6. Weiner HG, Voojis GP, Van’t Hof-Grootenboer B. Accuracy of urinary cytology in the diagnosis of primary and recurrent bladder cancer. Acta Cytol 1993;37(2):163-9. [PubMed]

7. Carmack AJ, Soloway MS. The diagnosis and staging of bladder cancer: From RBCs to TURS. Urology 2006;67(3 suppl 1):3-8;discussion-10. [PubMed]

8. Mitra AP, Birkhahn M, Penson DF,Cote RJ. Molecular screening for bladder cancer. Waltham,MA: Upto date;2009[cited October 2009]; Available from:http://www.uptodate.com.

9. Gilbert SM, Veltri RW, Sawczuk A, Shabsigh A, Knowels DR, Bright S, et al. Evaluation of DD23 as a marker for detection of recurrent transitional cell carcinoma of the bladder in patients with a history of bladder cancer. Urology 2003;61(3):539-43. [PubMed]

10. Van der Poel HG, Witjes JA, van Stratum P, Boon ME, Debruyne FM, Schalken JA. Quanticyt: karyometric analysis of bladder washing for patients with superficial bladder cancer. Urology,1996;48(3):357-64. [PubMed]

11. Halling KC, King W, Sokolova IA, Meyer RG, Burkhardt HM, Halling AC, et al. A comparision of cytology and flourescence in situ hybridization for the dwetection of urothelial carcinoma. J Urol 2000;164(5):1768-75. [PubMed]

12. Sokolova IA, Halling KC, Jenkins PB, Burkhardt HM, Meyer RG, Seelig SA, et al. The development of multi target, multicolor flourescence insitu hybridization for the detection of Urothelial carcinoma in urine. J Mol Diagn 2000;2(3):116-23.

13. Veeramachaneni R, Nordberg ML, Shi R, Herrera GA, Turbat-Herrara EA. Evaluation of flourescence in-situ hybridization as an ancillary tool to urine cytology in diagnosing urothelial carcinoma. Diagn Cytopathol 2003;28(6):301-7.
CITATION
DOI: 10.17511/ijmrr.2015.i1.05
Published: 2015-02-28
How to Cite
1.
Shanthi V, Rao BS, Rao CM, Grandhi DB, Reddy EC, Sreesailam F. The Diagnostic Efficacy of Urine Cytology in Screening Bladder Cancers: A Retrospective Study. Int J Med Res Rev [Internet]. 2015Feb.28 [cited 2024Nov.23];3(1):23-6. Available from: https://ijmrr.medresearch.in/index.php/ijmrr/article/view/179
Section
Original Article