To evaluate the relationship between BODE Index and CRP in COPD patients in a tertiary care centre
To evaluate the relationship between BODE Index and CRP in COPD patients in a tertiary care centre
Abstract
Background: Chronic obstructive pulmonary disease (COPD) is a respiratory disease which is associated with abnormal inflammatory response of lungs to stimuli leading to a progressive airflow limitation that is not fully reversible. COPD is the third leading cause of death worldwide with an estimated burden of COPD about 37.8million cases. Of late, the disease is being discussed widely due to its systemic nature. A combined index of multiple mortality predictors for COPD known as the “BODE index” was developed to understand this aspect of the disease. The BODE index, which includes Body Mass Index (BMI), Airflow Obstruction (FEV1), Dyspnea (MMRC), and Exercise Capacity (6MWT), is a multidimensional tool for assessing disease severity. C-reactive protein (CRP), an acute-phase reactant, is commonly elevated in COPD and may reflect systemic inflammatory burden.
Objective: This study aimed to evaluate the relationship between CRP levels and the BODE index in stable COPD patients.
Methods: A cross-sectional study was conducted on 110 stable COPD patients. CRP levels and BODE index components were measured and analyzed using Pearson coefficient correlation.
Results: A weak but statistically significant positive correlation was found between CRP and the BODE index (r = 0.258, p = 0.006). CRP was also significantly associated with lower FEV1, shorter 6MWT distance, and higher MMRC scores.
Conclusion: CRP may be a useful marker for systemic inflammation and disease severity in stable COPD patients.
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