An Evaluating the Accuracy of Endoscopic diagnosis : A comparative analysis with Histopathology in Upper and Lower GI Tract Disorders
Abstract
ABSTRACT
Background: Endoscopy and histopathology are complementary tools in diagnosing gastrointestinal (GI) disorders. While endoscopy provides macroscopic visualization, histopathology offers definitive microscopic diagnosis. This study aims to evaluate the correlation between endoscopic findings and histopathological results in upper and lower GI disorders.
Objectives:
- To assess the diagnostic correlation between endoscopic impressions and histopathological diagnosis.
- To determine the accuracy of endoscopy in detecting various upper and lower GI tract pathologies.
Methods: A retrospective study was conducted on 200 patients undergoing upper GI endoscopy (UGIE) and Colonoscopy for GI symptoms. Endoscopic findings were documented and correlated with histopathology reports of biopsy specimens.
Results: Endoscopic and histopathological findings were consistent in 92% of upper GI cases and 90.6% of lower GI cases. Among 125 upper GI cases, 115 were concordant, and among 75 lower GI cases, 68 were concordant. Highest correlation was observed in cases of gastric ulcers, esophagitis, colorectal polyps, and inflammatory bowel disease (IBD) and malignancy.
Conclusion: Endoscopy is a reliable initial diagnostic tool. However, histopathological confirmation is essential, especially in cases with subtle or ambiguous endoscopic findings.
Keywords: Endoscopy, Histopathology, GI Disorders, Upper GI, Colonoscopy.
Downloads
References
1. Chag S, Patel N, Rathod K. Endoscopic correlation with histological findings in upper gastrointestinal biopsies. International Journal of Clinical and Diagnostic Pathology. 2025;8(1):108-13.
2. Shankar U, Kumaria R, Sarmaikb A, Maribashetti K. A clinicopathological correlation of gastrointestinal lesions on endoscopic biopsies with positron emission tomography (pet) findings. International Journal of Medical Reviews and Case Reports (2022) 6(7):1-8.
3. Rashmi K, Horakerappa MS, Karar A, Mangala G. A study on histopathological spectrum of upper gastrointestinal tract endoscopic biopsies. Int J Med Res Health Sci. 2013; 2:418-24.
4. Ahlawat R, Hoilat GJ, Ross AB. Esophagogastroduodenoscopy Updated 2023 Aug 8]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK532268/?report=classic
5. Mohan B, Manjunath HK, Geethamani V, et al. Histomorphological Analysis of Upper GI Endoscopic Biopsies: A Retrospective Study of 106 Cases. National Journal of Laboratory Medicine. 2019 Oct, Vol-8(4): 4-7.
6. Stauffer CM, Pfeifer C. Colonoscopy. [Updated 2023 Jul 24]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK559274/?report=classic(new2)
7. Rauta S, Baisakh P, Sahoo A K, et al. Correlation of Endoscopic and Histopathological Diagnoses in Upper Gastrointestinal Tract Lesions: A Cross-Sectional Study. Cureus 16(9): e69553.
8. Patel J, Patel A, Throt R, et al. Study of Endoscopic and Histopathologic correlation in Upper Gastrointestinal lesions in a Tertiary Care Hospital.IJCRT | Volume 10, Issue 1 January 2022 | ISSN: 2320-882.
9. Sarma U, Kalita u. Clinicopathological Study of Gastroduodenal Biopsies and Correlate with Endoscopic. Pac J Cancer Biol, 9 (3), 265-9.
10. Mishra R, Vahikar S, Shrivastava K, et al. Histopathological spectrum of gastrointestinal lesions in patients undergoing gastrointestinal endoscopic biopsies- A ospective study. Trop J Pathol Microbiol. 2022;8(1):22-28.
11. Abilash, S. C., et al. Histopathologic spectrum of upper gastrointestinal tract mucosal biopsies: A retrospective study. " Sch. J. App. Med. Sci 4.5E (2016): 1807-13
12. Islam, Sk Md Jaynul, et al. Endoscopic and histologic diagnosis of upper gastrointestinal lesions, experience in a port city of Bangladesh. Chattagram Maa-O-Shishu Hospital Medical College Journal 13. 3 (2014): 11-14.
13. Krishnappa, Rashmi, et al. A study on histopathological spectrum of upper gastrointestinal tract endoscopic biopsies. International Journal of Medical Research & Health Sciences 2. 3 (2013): 418-24.
14. Sharma V, Bansal R, Sharma S, Khare A. Histopathological spectrum with clinical correlation of lower gastrointestinal tract endoscopic biopsies. International Journal of Clinical and Diagnostic Pathology 2022; 5(1): 89-93.

Copyright (c) 2025 Author (s). Published by Siddharth Health Research and Social Welfare Society

This work is licensed under a Creative Commons Attribution 4.0 International License.