A Case Report on Treatment of Pancreatoblastoma in a 55-year-old female
Treatment of Pancreatoblastoma
Keywords:
Pancreatoblastoma, amylase, lipase, Whipple procedure, immuno histochemistry
Abstract
Background: Pancreatoblastoma is a rare, malignant tumor develops in the pancreas and is distinguished by lobular structures which contain acinar cells and squamoid corpuscles. The most common site was head of the pancreas and most common symptom is abdominal pain and vomiting.Case Presentation: A 55-year-old female presented with complaints of abdominal pain and vomiting’s with vitals in normal range. However, her serum amylase and lipase levels were found to be elevated. A contrast-enhanced computed tomography (CECT) revealed a large exophytic mass lesion in her pancreas, measuring 6.5 x 9.3 x 8.5 cm and causes distortion of the SMV medially and stretching of the anterior superior pancreaticoduodenal vein. The main pancreatic duct is severely compressed. Our patient underwent a Whipple procedure and exhibited an unremarkable recovery.
Conclusion: Pancreatoblastoma is a curable tumor that requires early diagnosis through a multi-disciplinary approach. The tumor is removed completely by surgery and pathology; Immunohistochemistry confirms the diagnosis. Following surgery, the patient is closely monitored to look for any residual disease, metastases, or recurrences.Keywords: Pancreatoblastoma, amylase, lipase, Whipple procedure, immuno histochemistry
Downloads
Download data is not yet available.
References
1. Argon A, Çelik A, Öniz H, Özok G, Barbet FY. Pancreatoblastoma, a Rare Childhood Tumor: A Case Report. Turkish Journal of Pathology 2017;33(2):164-167.
2. Li J, Peng C, Fan X, Wang L, Wang J. Adult pancreatoblastoma: a case report. J Int Med Res. 2021;49(8):3000605211039565.
3. Cao L, Liu D. Diagnosis and treatment of pancreatoblastoma in China. Pancreas. 2007;34(1):92-5.
4. Omiyale AO. Adult pancreatoblastoma: Current concepts in pathology. World J Gastroenterol. 2021;27(26):4172-4181.
5. Horie A, Yano Y, Kotoo Y, Miwa A. Morphogenesis of pancreatoblastoma, infantile carcinoma of the pancreas: report of two cases. Cancer. 1977;39(1):247-54.
6. Yuan J, Guo Y, Li Y. Diagnosis, treatment, and prognosis of adult pancreatoblastoma. Cancer Med. 2024;13(16):e70132.
7. Morales GES, Payan HL, Valladares RAM, Rosado ID, Chan C. Adult pancreatoblastoma: A rare malignant tumor of the pancreas. Ann Hepatobiliary Pancreat Surg. 2021;25(3):436-439.
8. Veron Sanchez A, Santamaria Guinea N, Cayon Somacarrera S, Bennouna I, Pezzullo M, Bali MA. Rare Solid Pancreatic Lesions on Cross-Sectional Imaging. Diagnostics (Basel). 2023;13(16):2719.
9. Thera R, Souied O, Ahmed S, Hagel K, Chalchal H, Iqbal, M, et al. Pancreatoblastoma in adulthood: Case report and literature review. International Case Reports Journal. 2022; 2(7): 1-11.
10. Omiyale AO. Clinicopathological review of pancreatoblastoma in adults. Gland Surg. 2015;4(4):322-8.
11. Zhang X, Ni SJ, Wang XH, Huang D, Tang W. Adult pancreatoblastoma: clinical features and Imaging findings. Sci Rep. 2020;10(1):11285.
12. Stotz M, Barth DA, Riedl JM, Asamer E, Klocker EV, Kornprat P, et al. The Lipase/Amylase Ratio (LAR) in Peripheral Blood Might Represent a Novel Prognostic Marker in Patients with Surgically Resectable Pancreatic Cancer. Cancers. 2020; 12(7):1798.
13. Yang Y, Tian X. The management strategy of pancreatic cancer in the era of systemic therapy-"Surgery First" or "Surgery Last"? Hepatobiliary Surg Nutr. 2022;11(4):597-600.
14. Schmidt CM, Powell ES, Yiannoutsos CT, Howard TJ, Wiebke EA, Wiesenauer CA, et al. Pancreaticoduodenectomy: A 20-Year Experience in 516 Patients. The Archives of Surgery 2004;139(7):718–727.
15. Fuertes L, Santonja C, Kutzner H, Requena L. Immunohistochemistry in dermatopathology: a review of the most commonly used antibodies (part I). Actas Dermosifiliogr. 2013;104(2):99-127.
16. Naito Y, Kinoshita H, Okabe Y, Kawahara R, Sakai T, Suga H, et al. CD56 (NCAM) expression in pancreatic carcinoma and the surrounding pancreatic tissue. Kurume Med J. 2006; 53(3-4):59-62.
17. Tomita T. Significance of chromogranin A and synaptophysin in pancreatic neuroendocrine tumors. Bosn J Basic Med Sci. 2020;20(3):336-346.
18. Rosebrook JL, Glickman JN, Mortele KJ. Pancreatoblastoma in an adult woman: sonography, CT, and dynamic gadolinium-enhanced MRI features. AJR Am J Roentgenol. 2005;184(3 Suppl):S78-81.
2. Li J, Peng C, Fan X, Wang L, Wang J. Adult pancreatoblastoma: a case report. J Int Med Res. 2021;49(8):3000605211039565.
3. Cao L, Liu D. Diagnosis and treatment of pancreatoblastoma in China. Pancreas. 2007;34(1):92-5.
4. Omiyale AO. Adult pancreatoblastoma: Current concepts in pathology. World J Gastroenterol. 2021;27(26):4172-4181.
5. Horie A, Yano Y, Kotoo Y, Miwa A. Morphogenesis of pancreatoblastoma, infantile carcinoma of the pancreas: report of two cases. Cancer. 1977;39(1):247-54.
6. Yuan J, Guo Y, Li Y. Diagnosis, treatment, and prognosis of adult pancreatoblastoma. Cancer Med. 2024;13(16):e70132.
7. Morales GES, Payan HL, Valladares RAM, Rosado ID, Chan C. Adult pancreatoblastoma: A rare malignant tumor of the pancreas. Ann Hepatobiliary Pancreat Surg. 2021;25(3):436-439.
8. Veron Sanchez A, Santamaria Guinea N, Cayon Somacarrera S, Bennouna I, Pezzullo M, Bali MA. Rare Solid Pancreatic Lesions on Cross-Sectional Imaging. Diagnostics (Basel). 2023;13(16):2719.
9. Thera R, Souied O, Ahmed S, Hagel K, Chalchal H, Iqbal, M, et al. Pancreatoblastoma in adulthood: Case report and literature review. International Case Reports Journal. 2022; 2(7): 1-11.
10. Omiyale AO. Clinicopathological review of pancreatoblastoma in adults. Gland Surg. 2015;4(4):322-8.
11. Zhang X, Ni SJ, Wang XH, Huang D, Tang W. Adult pancreatoblastoma: clinical features and Imaging findings. Sci Rep. 2020;10(1):11285.
12. Stotz M, Barth DA, Riedl JM, Asamer E, Klocker EV, Kornprat P, et al. The Lipase/Amylase Ratio (LAR) in Peripheral Blood Might Represent a Novel Prognostic Marker in Patients with Surgically Resectable Pancreatic Cancer. Cancers. 2020; 12(7):1798.
13. Yang Y, Tian X. The management strategy of pancreatic cancer in the era of systemic therapy-"Surgery First" or "Surgery Last"? Hepatobiliary Surg Nutr. 2022;11(4):597-600.
14. Schmidt CM, Powell ES, Yiannoutsos CT, Howard TJ, Wiebke EA, Wiesenauer CA, et al. Pancreaticoduodenectomy: A 20-Year Experience in 516 Patients. The Archives of Surgery 2004;139(7):718–727.
15. Fuertes L, Santonja C, Kutzner H, Requena L. Immunohistochemistry in dermatopathology: a review of the most commonly used antibodies (part I). Actas Dermosifiliogr. 2013;104(2):99-127.
16. Naito Y, Kinoshita H, Okabe Y, Kawahara R, Sakai T, Suga H, et al. CD56 (NCAM) expression in pancreatic carcinoma and the surrounding pancreatic tissue. Kurume Med J. 2006; 53(3-4):59-62.
17. Tomita T. Significance of chromogranin A and synaptophysin in pancreatic neuroendocrine tumors. Bosn J Basic Med Sci. 2020;20(3):336-346.
18. Rosebrook JL, Glickman JN, Mortele KJ. Pancreatoblastoma in an adult woman: sonography, CT, and dynamic gadolinium-enhanced MRI features. AJR Am J Roentgenol. 2005;184(3 Suppl):S78-81.
How to Cite
1.
Priyanka, Vudayaraju H, V SS. A Case Report on Treatment of Pancreatoblastoma in a 55-year-old female. Int J Med Res Rev [Internet]. 2025Jul.11 [cited 2025Jul.12];13(2):41-5. Available from: https://ijmrr.medresearch.in/index.php/ijmrr/article/view/1552
Section
Case Report
Copyright (c) 2025 Author (s). Published by Siddharth Health Research and Social Welfare Society
This work is licensed under a Creative Commons Attribution 4.0 International License.
OAI - Open Archives Initiative
