Challenges and Opportunities in Normothermic Liver Perfusion: A Standard Research Review from an Indian Perspective

  • Gautam K Meril Medical Innovations Private Limited, Bilakhia House, Survey no.879, Muktanand Marg, Chala, Vapi, Dist.-Valsad, Gujarat, 396191, India
  • Kothwala D Meril Medical Innovations Private Limited, Bilakhia House, Survey no.879, Muktanand Marg, Chala, Vapi, Dist.-Valsad, Gujarat, 396191, India
  • Durani O Meril Medical Innovations Private Limited, Bilakhia House, Survey no.879, Muktanand Marg, Chala, Vapi, Dist.-Valsad, Gujarat, 396191, India
  • Jithendran A Meril Medical Innovations Private Limited, Bilakhia House, Survey no.879, Muktanand Marg, Chala, Vapi, Dist.-Valsad, Gujarat, 396191, India
Keywords: Normothermic Liver Perfusion, Liver Transplantation, Organ Preservation, Challenges, Opportunities

Abstract

Liver transplantation is the only definitive treatment for end-stage liver disease and acute liver failure; however, the shortage of viable donor organs remains a critical challenge. Conventional static cold storage (SCS), while widely used, is associated with ischemia-reperfusion injury, leading to suboptimal graft function. Normothermic liver perfusion (NLP) has emerged as an advanced preservation technique that mimics physiological conditions, thereby reducing cellular injury, extending preservation times, and improving organ viability. Studies have demonstrated that NLP enhances graft recovery, facilitates viability assessment, and increases the utilization of marginal donor livers. Despite these advantages, the implementation of NLP in India is hindered by high costs, infrastructure limitations, and the need for specialized expertise. However, with increased investment in healthcare, research collaborations, and regulatory support, NLP could revolutionize liver transplantation in India by improving transplant outcomes and expanding the donor pool. This review explores the clinical benefits, challenges, and potential pathways for integrating NLP into India’s organ transplantation framework, highlighting the need for strategic policy interventions, cost-effective solutions, and workforce training to enable widespread adoption.

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How to Cite
1.
Gautam K, Deveshkumar K, Ovesh D, Jithendran A. Challenges and Opportunities in Normothermic Liver Perfusion: A Standard Research Review from an Indian Perspective. Int J Med Res Rev [Internet]. 2025Apr.21 [cited 2025May15];13(2):20-6. Available from: https://ijmrr.medresearch.in/index.php/ijmrr/article/view/1540
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Review Article