CASE REPORT CREST Syndrome: A Rare Cause of Chronic Upper-Gastro Intestinal Haemorrhage in Adults
Abstract
ABSTRACT:
Background: CREST syndrome, a limited cutaneous variant of systemic sclerosis, rarely presents with chronic upper gastrointestinal haemorrhage. This case report explores the complex pathological mechanisms and management challenges of this uncommon manifestation.
Case Presentation: A 52-year-old female with established CREST syndrome presented with recurrent melena and hematemesis. Comprehensive clinical evaluation revealed extensive gastrointestinal telangiectasia with significant bleeding potential. Upper endoscopy demonstrated multiple fragile vascular lesions throughout the esophagus, stomach, and duodenum.The patient underwent detailed diagnostic imaging, including CT angiography and capsule endoscopy. Therapeutic interventions included argon plasma coagulation, tranexamic acid therapy, and systemic immunosuppression with mycophenolatemofetil.
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References
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