Preventive Aspects of Vitamin D and Health; an Overview
Keywords:
Vitamin D, Preventive Medicine, Chronic Disease
Abstract
Bioactive vitamin D or calcitriol is a steroid hormone that has long been known for its role in regulating body levels of calcium and phosphorus, and in mineralization of bone. Research also suggests that vitamin D is important for muscle strength and performance, stimulates the immune system, helps to treat infection and protects against autoimmune diseases and more than a dozen type of cancer, including prostate, breast and colon cancer. The relevance of the frequently low vitamin D status is not completely clear. There is growing evidence for the contribution of a circulating 25(OH)D level below 50 nmol/l to the development of various chronic diseases.
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References
1. DeLuca HF. Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr. 2004, 80(6); 1689S-1696S. [PubMed]
2. Hollick MF. The vitamin D deficiency pandemic: a forgotten hormone important for health. Public Health Review. 2010, 32(1); 267-283.
3. Marwaha RK, Tandon N, Reddy DR, Aggarwal R, Singh R, Sawhney RC, Saluja B, Ganie MA, Singh S. Vitamin D and bone mineral density status of healthy schoolchildren in northern India. Am J Clin Nutr. 2005 ; 82(2):477-82. [PubMed]
4. Sachan A, Gupta R, Das V, Agarwal A, Awasthi PK, Bhatia V. High prevalence of vitamin D deficiency among pregnant women and their newborns in northern India. Am J Clin Nutr. 2005; 81(5):1060-4. [PubMed]
5. Harinarayan CV, Joshi SR. Vitamin D status in India- its implications and remedial measures. J Assoc Physicians India. 2009, 57 , 40-48. [PubMed]
6. Lin JT, Lane JM. Metabolic Bone Disease. In; Weinstein Stuart L., Buckwalter Joseph A. Editors. Turek's Orthopaedics: Principles and Their Application. 6th Edition. Lippincott Williams & Wilkins Publishing. 2005.
7. Bouillon R, Carmeliet G, Daci E, Segaert S, Verstuyf A. Vitamin D Metabolism and Action; Osteoporosis International 1998, 8, S13–S19. [PubMed]
8. Rosen CJ, Adams JS, Bikle DD, Black DM, Demay MB, Manson JE, Murad MH, Kovacs CS. The nonskeletal effects of Vitamin D: an endocrine society scientific statement. Endocr Rev. 2012, 33(3), 456-492. [PubMed]
9. Cianferroti L, Marcocci C. Subclinical vitamin D deficiency; Best Pract Res Clin Endocrinol Metab. 2012, 26(4): 523-537. [PubMed]
10. Rasheed K, Sethi P, Bixby E. Severe Vitamin D Deficiency Induced Myopathy Associated with Rhabydomyolysis; N Am J Med Sci. 2013; 5(5): 334–336.
11. Glueck CJ, Conrad B. Severe Vitamin D Deficiency, Myopathy, and Rhabdomyolysis; N Am J Med Sci. Aug 2013; 5(8): 494–495. [PubMed]
12. Gupta R, Sharma U, Gupta N, Kalaivani M, Singh U, Guleria R, Jagannathan NR, Goswami R. 2010. Effect of cholecalciferol and calcium supplementation on muscle strength and energy metabolism in vitamin D deficient Asian Indians: a randomized controlled trial. Clin Endocrinol (Oxf) 73:445–451. [PubMed]
13. McCarroll KC, Robinson DJ, Coughlan A, Healy M, Kenny RA, Cunningham C. Vitamin D and orthostatic hypotension; Age and Ageing 2012; 0:1-4. [PubMed]
14. Soysal P, Yay A, Isik AT. Does vitamin D deficiency increase orthostatic hypotension risk in the elderly patients?; Archives of Gerontology and Geriatrics 2014, 59(1); 74–77. [PubMed]
15. Lawson DE, Cole TJ, Salem SI, Galal OM, ElMeligy R, Azim AS, Paul AA, ElHusseini S. Aetiology of rickets in Egyptian children; Human Nutrition Clinical Nutrition 1987, 41, 199–208. [PubMed]
16. Salahuddin N, Ali F, Hasan Z, Rao N, Aqeel M, Mahmood F. Vitamin D accelerates clinical recovery from tuberculosis: results of the SUCCINCT Study [Supplementary Cholecalciferol in recovery from tuberculosis]. A randomized, placebo-controlled, clinical trial of vitamin D supplementation in patients with pulmonary tuberculosis. BMC Infectious Diseases 2013, 13:22 doi:10.1186/1471-2334-13-22. [PubMed]
17. Pryke AM, Duggan C, White CP, Posen S, Mason RS. Tumor necrosis factor-alpha induces vitamin D-1-hydroxylase activity in normal human alveolar macrophages; Journal of Cell Physiology 1990, 142, 652–656.
18. Song Y, Wang L, Pittas AG, Gobbo LCD, Zhang C, Manson JE, Hu FB. Blood 25-hydoxy vitamin d levels and incident type 2 diabetes. Diabetes care 2013: 36: 1422-1428. [PubMed]
19. Haynes BF, Anthony S. Introduction to the Immune System. In Kasper DL, Fauci AS, Longo DL, Braunwald E, Hauser SL, Jameson JL. Editors. Harrison's Principles of Internal Medicine 16th Edition. McGraw-Hills Publication 2004. [PubMed]
20. Mouli VP, Ananthakrishnan AN. Vitamin D and Inflammatory Bowel Diseases: Aliment Pharmacol Ther. 2014; 39(2):125-136. [PubMed]
21. Joseph AJ, George B, Pulimood AB, Seshadri MS, Chacko A. 25(OH) Vitamin D level in Crohn.s disease: association with sun exposure & disease activity. Indian J Med Res 130, 2009, 130, 133-137.
22. Cantorna MT, Mahon BD, Bemiss CJ, Gordon SA, Cruz JD, Cosman F. Altered cytokine profile in patients with multiple sclerosis following vitamin D supplementation; Annals of Nutrition and Metabolism 2001, 45, Suppl., 290 Abstract.
23. McAlindon TE, Felson DT, Zhang Y, Hannan MT, Aliabadi P, Weissman B, Rush D, Wilson PWF. Relation of dietary intake and serum levels of vitamin D to progression of osteoarthritis of the knee among participants in the Framingham study; Annals of Internal Medicine 1996, 125, 353–359.
24. Demir M, Uyan U, Keçeoçlu S, Demir C: The relationship between vitamin D deficiency and pulmonary hypertension; Prague Med Rep. 2013;114(3):154-61. [PubMed]
25. Lee JH, O'Keefe JH, Bell D, Hensrud DD, Holick MF. Vitamin D deficiency an important, common, and easily treatable cardiovascular risk factor? J am coll cardiology. 2008 dec 9;52(24): 1949-56. [PubMed]
26. Gouni-Berthold I, Krone W, Berthold HK. Vitamin D and cardiovascular disease; Curr Vasc Pharmacol. 2009 Jul;7(3):414-22.
27. Chaudhuri JR, Mridula KR, Alladi S, Anamika A, Umamahesh M, Balaraju Banda, Swath A, Bandaru S. Serum 25-hydroxyvitamin d deficiency in ischemic stroke and subtypes in indian patients; Journal of Stroke 2014;16(1) :44-50. [PubMed]
28. Forman JP, Giovannucci E, Holmes MD, Bischoff-Ferrari HA, Tworoger SS, Willett WC, Curhan GC. Plasma 25-hydroxyvitamin D levels and risk of incident hypertension. Hypertension. 2007; 49(5):1063-9.
29. Luong KV, Nguyen LTH. The beneficial role of vitamin D in obesity: possible genetic and cell signaling mechanisms; Nutrition Journal 2013, 12(89); doi:10.1186/1475-2891-12-89. [PubMed]
30. Khashayar P, Meybodi HRA, Soltani A, Taheri E, Homami MR, Heshmat R, Dimai HP, Larijani B. Association between Vitamin D levels and BMI values in an Iranian Population; Clin.Lab. 2014; 60: 383-389. [PubMed]
31. Cui Y, Rohan TE. Vitamin D, calcium, and breast cancer risk: a review; Cancer Epidemiol Biomarkers Prev 2006;15(8):1427-37. [PubMed]
32. Murphy AB, Nyame Y, Martin IM, CatalonaWJ, Hollowell CMP, Nadler RB, Kozlowski JM, Perry KT, Kajdacsy-Balla A, Kittles R. Vitamin D Deficiency Predicts Prostate Biopsy Outcomes; Clin Cancer Res; 20(9); 2289–99. [PubMed]
33. Heaney RP. Assessing vitamin D status; Curr Opin Clin Nutr Metab Care. 2011, 14(5):440-4. [PubMed]
34. Zittermann A. Vitamin D in preventive medicine: are we ignoring evidence? British Journal of Nutrition, 2003, 89, 552-572.
2. Hollick MF. The vitamin D deficiency pandemic: a forgotten hormone important for health. Public Health Review. 2010, 32(1); 267-283.
3. Marwaha RK, Tandon N, Reddy DR, Aggarwal R, Singh R, Sawhney RC, Saluja B, Ganie MA, Singh S. Vitamin D and bone mineral density status of healthy schoolchildren in northern India. Am J Clin Nutr. 2005 ; 82(2):477-82. [PubMed]
4. Sachan A, Gupta R, Das V, Agarwal A, Awasthi PK, Bhatia V. High prevalence of vitamin D deficiency among pregnant women and their newborns in northern India. Am J Clin Nutr. 2005; 81(5):1060-4. [PubMed]
5. Harinarayan CV, Joshi SR. Vitamin D status in India- its implications and remedial measures. J Assoc Physicians India. 2009, 57 , 40-48. [PubMed]
6. Lin JT, Lane JM. Metabolic Bone Disease. In; Weinstein Stuart L., Buckwalter Joseph A. Editors. Turek's Orthopaedics: Principles and Their Application. 6th Edition. Lippincott Williams & Wilkins Publishing. 2005.
7. Bouillon R, Carmeliet G, Daci E, Segaert S, Verstuyf A. Vitamin D Metabolism and Action; Osteoporosis International 1998, 8, S13–S19. [PubMed]
8. Rosen CJ, Adams JS, Bikle DD, Black DM, Demay MB, Manson JE, Murad MH, Kovacs CS. The nonskeletal effects of Vitamin D: an endocrine society scientific statement. Endocr Rev. 2012, 33(3), 456-492. [PubMed]
9. Cianferroti L, Marcocci C. Subclinical vitamin D deficiency; Best Pract Res Clin Endocrinol Metab. 2012, 26(4): 523-537. [PubMed]
10. Rasheed K, Sethi P, Bixby E. Severe Vitamin D Deficiency Induced Myopathy Associated with Rhabydomyolysis; N Am J Med Sci. 2013; 5(5): 334–336.
11. Glueck CJ, Conrad B. Severe Vitamin D Deficiency, Myopathy, and Rhabdomyolysis; N Am J Med Sci. Aug 2013; 5(8): 494–495. [PubMed]
12. Gupta R, Sharma U, Gupta N, Kalaivani M, Singh U, Guleria R, Jagannathan NR, Goswami R. 2010. Effect of cholecalciferol and calcium supplementation on muscle strength and energy metabolism in vitamin D deficient Asian Indians: a randomized controlled trial. Clin Endocrinol (Oxf) 73:445–451. [PubMed]
13. McCarroll KC, Robinson DJ, Coughlan A, Healy M, Kenny RA, Cunningham C. Vitamin D and orthostatic hypotension; Age and Ageing 2012; 0:1-4. [PubMed]
14. Soysal P, Yay A, Isik AT. Does vitamin D deficiency increase orthostatic hypotension risk in the elderly patients?; Archives of Gerontology and Geriatrics 2014, 59(1); 74–77. [PubMed]
15. Lawson DE, Cole TJ, Salem SI, Galal OM, ElMeligy R, Azim AS, Paul AA, ElHusseini S. Aetiology of rickets in Egyptian children; Human Nutrition Clinical Nutrition 1987, 41, 199–208. [PubMed]
16. Salahuddin N, Ali F, Hasan Z, Rao N, Aqeel M, Mahmood F. Vitamin D accelerates clinical recovery from tuberculosis: results of the SUCCINCT Study [Supplementary Cholecalciferol in recovery from tuberculosis]. A randomized, placebo-controlled, clinical trial of vitamin D supplementation in patients with pulmonary tuberculosis. BMC Infectious Diseases 2013, 13:22 doi:10.1186/1471-2334-13-22. [PubMed]
17. Pryke AM, Duggan C, White CP, Posen S, Mason RS. Tumor necrosis factor-alpha induces vitamin D-1-hydroxylase activity in normal human alveolar macrophages; Journal of Cell Physiology 1990, 142, 652–656.
18. Song Y, Wang L, Pittas AG, Gobbo LCD, Zhang C, Manson JE, Hu FB. Blood 25-hydoxy vitamin d levels and incident type 2 diabetes. Diabetes care 2013: 36: 1422-1428. [PubMed]
19. Haynes BF, Anthony S. Introduction to the Immune System. In Kasper DL, Fauci AS, Longo DL, Braunwald E, Hauser SL, Jameson JL. Editors. Harrison's Principles of Internal Medicine 16th Edition. McGraw-Hills Publication 2004. [PubMed]
20. Mouli VP, Ananthakrishnan AN. Vitamin D and Inflammatory Bowel Diseases: Aliment Pharmacol Ther. 2014; 39(2):125-136. [PubMed]
21. Joseph AJ, George B, Pulimood AB, Seshadri MS, Chacko A. 25(OH) Vitamin D level in Crohn.s disease: association with sun exposure & disease activity. Indian J Med Res 130, 2009, 130, 133-137.
22. Cantorna MT, Mahon BD, Bemiss CJ, Gordon SA, Cruz JD, Cosman F. Altered cytokine profile in patients with multiple sclerosis following vitamin D supplementation; Annals of Nutrition and Metabolism 2001, 45, Suppl., 290 Abstract.
23. McAlindon TE, Felson DT, Zhang Y, Hannan MT, Aliabadi P, Weissman B, Rush D, Wilson PWF. Relation of dietary intake and serum levels of vitamin D to progression of osteoarthritis of the knee among participants in the Framingham study; Annals of Internal Medicine 1996, 125, 353–359.
24. Demir M, Uyan U, Keçeoçlu S, Demir C: The relationship between vitamin D deficiency and pulmonary hypertension; Prague Med Rep. 2013;114(3):154-61. [PubMed]
25. Lee JH, O'Keefe JH, Bell D, Hensrud DD, Holick MF. Vitamin D deficiency an important, common, and easily treatable cardiovascular risk factor? J am coll cardiology. 2008 dec 9;52(24): 1949-56. [PubMed]
26. Gouni-Berthold I, Krone W, Berthold HK. Vitamin D and cardiovascular disease; Curr Vasc Pharmacol. 2009 Jul;7(3):414-22.
27. Chaudhuri JR, Mridula KR, Alladi S, Anamika A, Umamahesh M, Balaraju Banda, Swath A, Bandaru S. Serum 25-hydroxyvitamin d deficiency in ischemic stroke and subtypes in indian patients; Journal of Stroke 2014;16(1) :44-50. [PubMed]
28. Forman JP, Giovannucci E, Holmes MD, Bischoff-Ferrari HA, Tworoger SS, Willett WC, Curhan GC. Plasma 25-hydroxyvitamin D levels and risk of incident hypertension. Hypertension. 2007; 49(5):1063-9.
29. Luong KV, Nguyen LTH. The beneficial role of vitamin D in obesity: possible genetic and cell signaling mechanisms; Nutrition Journal 2013, 12(89); doi:10.1186/1475-2891-12-89. [PubMed]
30. Khashayar P, Meybodi HRA, Soltani A, Taheri E, Homami MR, Heshmat R, Dimai HP, Larijani B. Association between Vitamin D levels and BMI values in an Iranian Population; Clin.Lab. 2014; 60: 383-389. [PubMed]
31. Cui Y, Rohan TE. Vitamin D, calcium, and breast cancer risk: a review; Cancer Epidemiol Biomarkers Prev 2006;15(8):1427-37. [PubMed]
32. Murphy AB, Nyame Y, Martin IM, CatalonaWJ, Hollowell CMP, Nadler RB, Kozlowski JM, Perry KT, Kajdacsy-Balla A, Kittles R. Vitamin D Deficiency Predicts Prostate Biopsy Outcomes; Clin Cancer Res; 20(9); 2289–99. [PubMed]
33. Heaney RP. Assessing vitamin D status; Curr Opin Clin Nutr Metab Care. 2011, 14(5):440-4. [PubMed]
34. Zittermann A. Vitamin D in preventive medicine: are we ignoring evidence? British Journal of Nutrition, 2003, 89, 552-572.
CITATION
DOI: 10.17511/ijmrr.2014.i05.19
Published: 2014-10-31
How to Cite
1.
Faruqui S, Choubey R. Preventive Aspects of Vitamin D and Health; an Overview. Int J Med Res Rev [Internet]. 2014Oct.31 [cited 2024Jul.3];2(5):491-5. Available from: https://ijmrr.medresearch.in/index.php/ijmrr/article/view/148
Section
Review Article
OAI - Open Archives Initiative
