Superbugs Unleashed: Is Time Running Out to Stop the Global Infection Crisis?
Superbugs Unleashed: The Urgency of Addressing the Global Infection Crisis
Abstract
The global infection crisis poses a significant threat to public health, with the emergence and spread of antibiotic-resistant bacteria or "superbugs" becoming a major concern. The crisis has been fueled by various factors, including overuse of antibiotics, inadequate infection prevention and control measures, and the lack of investment in research and development of new treatments. Addressing this issue requires a comprehensive approach that involves improving surveillance and monitoring systems, promoting individual responsibility, and investing in research and development. Collaboration between stakeholders, including governments, healthcare providers, researchers, and the public, is crucial in overcoming the challenges posed by the global infection crisis. Despite promising advances in emerging technologies, sustained investment in research and development is necessary to ensure continued progress in addressing the issue. Failure to take action risks a future where superbugs run rampant and existing treatments become ineffective. It is time to act decisively to halt the spread of superbugs and prevent a global health crisis.
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References
2. Ventola CL. The antibiotic resistance crisis: part 1: causes and threats. P T. 2015;4:277-83.
3. Review on Antimicrobial Resistance. Tackling drug-resistant infections globally: final report and recommendations;2016. https://amrreview.org/sites/default/files/160518_Final%20paper_with%20cover.pdf [Last accessed on 2023 Apr18].
4. World Health Organization. Antibiotic Resistance. Available from: https://www.who.int/news-room/fact-sheets/detail/antibiotic-resistance. [Last accessed on 2023 Apr18].
5. Centers for Disease Control and Prevention. Antibiotic Resistance Threats in the United States;2019. Available from: https://www.cdc.gov/drugresistance/pdf/threats-report/2019-ar-threats-report-508.pdf. [Last accessed on 2023 Apr18].
6. World Health Organization. COVID-19 and Antimicrobial Resistance. Available from: https://www.who.int/health-topics/coronavirus/antimicrobial-resistance. /.[Last accessed on 2023 Apr 14].
7. O'Neill J. Tackling drug-resistant infections globally: final report and recommendations. The review on antimicrobial resistance;2016. Available from: https://wellcomecollection.org/works/thvwsuba/.[Last accessed on 2023 Apr 20].
8. Food and Agriculture Organization of the United Nations. Antimicrobial Resistance in the Food Chain;2019 Available from: http://www.fao.org/antimicrobial-resistance/key-action-areas/food-chain/en/.[Last accessed on 2023 Apr 14].
9. Centers for Disease Control and Prevention. Methicillin-resistant Staphylococcus aureus (MRSA);2023 Available from: https://www.cdc.gov/mrsa/index.html. /.[Last accessed on 2023 Apr 14].
10. World Health Organization. Global Priority List of Antibiotic-resistant Bacteria to Guide Research, Discovery, and Development of New Antibiotics. Available from: https://www.who.int/medicines/publications/global-priority-list-antibiotic-resistant-bacteria/en/.[Last accessed on 2023 Apr 19].
11. Centers for Disease Control and Prevention. Antibiotic Resistance Threats in the United States;2019. Available from: https://www.cdc.gov/drugresistance/pdf/threats-report/2019-ar-threats-report-508.pdf. [Last accessed on 2023 Apr 24].
12. Laxminarayan R, Duse A, Wattal C, et al. Antibiotic resistance—the need for global solutions. Lancet Infect Dis. 2013 ;12:1057-98.
13. Howard SJ, Catchpole M, Watson J, et al. Antibiotic resistance: global response needed. Lancet Infect Dis. 2013;12:1001-3
14. O’Neill J. Antimicrobial Resistance: Tackling a Crisis for the Health and Wealth of Nations. Review on Antimicrobial Resistance 2014;1-16.
15. Morens DM, Folkers GK, Fauci AS. The challenge of emerging and re-emerging infectious diseases. Nature. 2004 ;6996:242-9.
16. Bloom DE, Black S, Rappuoli R. Emerging infectious diseases: a proactive approach. Proc Natl Acad Sci U S A 2017 ;16:4055-9.
17. World Health Organization. Global Action Plan on Antimicrobial Resistance. Available from: https://www.who.int/publications/i/item/9789241509763. [Last accessed on 2023 Apr 24].
18. Centers for Disease Control and Prevention. Antibiotic Resistance Threats in the United States:2019. Available from: https://www.cdc.gov/drugresistance/pdf/threats-report/2019-ar-threats-report-508.pdf. [Last accessed on 2023 Apr 22].
19. Pehrsson EC, Tsukayama P, Patel S, et al. Interconnected microbiomes and resistomes in low-income human habitats. Nature 2016 ;7602:212-6.
20. World Health Organization. WHO Guidelines on Hand Hygiene in Health Care: First Global Patient Safety Challenge Clean Care Is Safer Care. Geneva: World Health Organization; 2009.Available from https://www.who.int/publications/i/item/9789241597906 [Last accessed on 2023 Apr 22].
21. Chen Y, Sheng WH, Wang JT, et al. Effectiveness and limitations of hand hygiene promotion on decreasing healthcare-associated infections. PLoS One 2011;11: e27163.
22. The Combating Antibiotic-Resistant Bacteria Biopharmaceutical Accelerator (CARB-X).
Available from https://carb-x.org/about/overview/ [Last Accessed on 2023 April 20]
23. HM Government. UK 5 Year Action Plan for Antimicrobial Resistance 2019 to 2024. London: HM Government; 2019. Available from: https://www.gov.uk/government/publications/uk-5-year-action-plan-for-antimicrobial-resistance-2019-to-2024. [Last accessed on 2023 Apr 22].
24. Australian Government. National Antimicrobial Resistance Strategy 2020 and Beyond. Canberra: Department of Health; 2020. Available from: https://www1.health.gov.au/internet/main/publishing.nsf/Content/ohp-antimicrobial-2019.htm. [Last Accessed on 2023 April 20]
25. European Centre for Disease Prevention and Control. European Antibiotic Awareness Day (EAAD). Stockholm: ECDC;2022. Available from: https://www.ecdc.europa.eu/en/antimicrobial-resistance-and-consumption/european-antibiotic-awareness-day. [Last accessed on 2023 Apr 20]
26. Centers for Disease Control and Prevention. Get Smart About Antibiotics Week. Atlanta: CDC; 2021. Available from: https://www.cdc.gov/antibiotic-use/week/index.html. [Last accessed on 2023 Apr 20]
27. Citorik RJ, Mimee M, Lu TK. Sequence-specific antimicrobials using efficiently delivered RNA-guided nucleases. Nat Biotechnol 2014;11:1141-5.
28. Fauconnier A. Phage therapy regulation: from night to dawn. Viruses 2019;4:352.
29. World Health Organization. Antimicrobial resistance: global report on surveillance 2014. Geneva: World Health Organization; 2014. Available from: https://www.who.int/antimicrobial-resistance/publications/surveillancereport/en/ [Last accessed on 2023 Apr 24].
30. Tängdén T, Cars O, Melhus Å, Löwdin E. Foreign travel is a major risk factor for colonization with Escherichia coli producing CTX-M-type extended-spectrum β-lactamases: a prospective study with Swedish volunteers. Antimicrob Agents Chemother 2010 ;12:3564-8.
31. Graham JP, Boland JJ, Silbergeld E. Growth promoting antibiotics in food animal production: an economic analysis. Public Health Rep 2007 ;1:79-87.
32. Pruden A, Arabi M, Storteboom HN. Correlation between upstream human activities and riverine antibiotic resistance genes. Environ Sci Technol 2012 ;14 :11541-9.
33. Review on Antimicrobial Resistance. Tackling drug-resistant infections globally: final report and recommendations. London: Review on Antimicrobial Resistance; 2016. Available from: https://amrreview.org/sites/default/files/160525_Final%20paper_with%20cover.pdf [Last accessed on 2023 Apr 24].
34. World Bank. Drug-resistant infections: a threat to our economic future. Washington, DC: World Bank; 2017. Available from: https://www.worldbank.org/en/topic/health/brief/drug-resistant-infections-a-threat-to-our-economic-future [Last accessed on 2023 Apr 24].
35. Littmann J, Viens AM. The ethical significance of antimicrobial resistance. Public Health Ethics 2015;3: 209-24.
36. Emanuel EJ, Persad G, Upshur R,et al. Fair allocation of scarce medical resources in the time of Covid-19. N Engl J Med 2020 ;21:2049-55.
37. Hoffman SJ, Outterson K. What will it take to address the global threat of antibiotic resistance? J Law Med Ethics 2015;3:363-8.
38. Laxminarayan R, Matsoso P, Pant S, et al. Access to effective antimicrobials: a worldwide challenge. Lancet 2016;10014:168-75.
39. Pittet D, Donaldson L, Clean Care is Safer Care programme, WHO. Clean care is safer care: a worldwide priority. Lancet. 2005 ;9493:1246-47.
40. Hoffman SJ, Outterson K, Røttingen J-A. Towards global collective action on antimicrobial resistance. Lancet Infect Dis 2015;11:1252-58.
41. Outterson K, McDonnell A, Cox E. Clustering strategies for antibiotic conservation. In: VanDeveer S, editor. The Palgrave Handbook of the International Political Economy of Energy. London: Palgrave Macmillan UK; 2016.1-28.
42. One Health Initiative. About the One Health Initiative [Internet]. [place unknown]: One Health Initiative; [date unknown] .Available from: https://www.onehealthinitiative.com/about.php [Last accessed on 2023 Apr 24].
43. American Veterinary Medical Association. One Health: A New Professional Imperative [Internet]. [place unknown]: American Veterinary Medical Association. Available from: https://www.avma.org/resources-tools/one-health [Last accessed on 2023 Apr 23]
44. World Health Organization. One Health [Internet]. Geneva: World Health Organization; 2018. Available from: https://www.who.int/news-room/q-a-detail/one-health. [Last accessed on 2023 Apr 23]
45. Gibbs EPJ. The evolution of One Health: A decade of progress and challenges for the future. Vet Rec 2014;4:85-91.
46. Centers for Disease Control and Prevention. Antibiotic Resistance & One Health [Internet]. Atlanta (GA): Centers for Disease Control and Prevention; 2022.Available from: https://www.cdc.gov/drugresistance/one-health.html [Last accessed on 2023 Apr 23]
47. World Health Organization. Global Action Plan on Antimicrobial Resistance [Internet]. Geneva: World Health Organization; 2015. Available from: https://www.who.int/publications/i/item/9789241509763
[Last accessed on 2023 Apr 23]
48. Centers for Disease Control and Prevention. Antibiotic resistance threats in the United States, 2019 [Internet]. Atlanta (GA): Centers for Disease Control and Prevention; 2021. Available from: https://www.cdc.gov/drugresistance/biggest-threats.html [Last accessed on 2023 Apr 23]
49. World Health Organization. Global antimicrobial resistance surveillance system (GLASS) report: Early implementation 2020 [Internet]. Geneva: World Health Organization; 2019. Available from: https://www.who.int/publications/i/item/9789240005583 [Last accessed on 2023 Apr 23]
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