Albahkali, et al The general skeletal features of Multicentric Carpotarsal Osteolysis: what the radiologist needs to know
Keywords:
Multicentric carpo-tarsalcartotharsal osteolysis, Skeleton, MAFB, Radiologist, Nephropathy
Abstract
Radiographic imaging is the first investigational step in detecting of MCTO, and the radiologist must be aware then familiar with the radiolgical features in order both to reach a prompt diagnosis and then to classify the patient’s condition at this important time for considering early management. Here we review the literature on this topic. Patients with MCTO are frequently diagnosed with JIA. Initially. Among the many published studies, some are case reports that describe the phenotypical manifestations with a brief discussion of the radiographic findings and subsequently of the genetic analysis which eventually leads to a definitive diagnosis. Some patients develop end stage renal failure, and a delay in identifying this condition can lead to unfavorable progression of the disease. In addition, we found reports of joint inflammation based on imaging and of pain relief with antirheumatics for osteolysis and bone destruction. Various studies discuss the radiological findings, including the disappearance of the carpal and tarsal bones. Others describe the genetic mutations, including MAFB, that are associated with the condition, and its possible management through the use of therapeutic drugs. A very recent description of serial radiographs taken from a young age suggests that dysfunctional bone formation can play a role in the skeletal phenotype of MCTO. The atypical radiological findings, failure to obtain remission with medical treatment and consanguinity, should guide clinicians toward diagnosis. We summarize the X-ray findings which are highly specific and can therefore differentiate between this condition and others. Further performance of genetic tests is confirmative.
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References
References:
1. Upadia, J., Gomes, A., Weiser, P., & Descartes, M. (2018). A Familial Case of Multicentric Carpotarsal Osteolysis Syndrome and Treatment Outcome. Journal of pediatric genetics, 7(4), 174–179. https://doi.org/10.1055/s-0038-1657760
2. Peeters, J., Vanhoenacker, F. M., Mortier, G., & Parizel, P. M. (2011). Multicentric carpal-tarsal osteolysis. JBR-BTR : organe de la Societe royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR), 94(4), 218. https://doi.org/10.5334/jbr-btr.641
3. Park, P. G., Kim, K. H., Hyun, H. S., Lee, C. H., Park, J. S., Kie, J. H., Choi, Y. H., Moon, K. C., & Cheong, H. I. (2018). Three cases of multicentric carpotarsal osteolysis syndrome: a case series. BMC medical genetics, 19(1), 164. https://doi.org/10.1186/s12881-018-0682-x
4. Mehawej, C., Courcet, J. B., Baujat, G., Mouy, R., Gérard, M., Landru, I., Gosselin, M., Koehrer, P., Mousson, C., Breton, S., Quartier, P., Le Merrer, M., Faivre, L., & Cormier-Daire, V. (2013). The identification of MAFB mutations in eight patients with multicentric carpo-tarsal osteolysis supports genetic homogeneity but clinical variability. American journal of medical genetics. Part A, 161A(12), 3023–3029. https://doi.org/10.1002/ajmg.a.36151
5. Wenkert, D., Mumm, S., Wiegand, S. M., McAlister, W. H., & Whyte, M. P. (2007). Absence of MMP2 mutation in idiopathic multicentric osteolysis with nephropathy. Clinical orthopedorthopaedics and related research, 462, 80–86. https://doi.org/10.1097/BLO.0b013e3180d09db8.
6. Dworschak, G. C., Draaken, M., Hilger, A., Born, M., Reutter, H., & Ludwig, M. (2013). An incompletely penetrant novel MAFB (p.Ser56Phe) variant in autosomal dominant multicentric carpotarsal osteolysis syndrome. International journal of molecular medicine, 32(1), 174–178. https://doi.org/10.3892/ijmm.2013.1373
7. Wu, J., Wang, L., Xu, Y., Zhang, Z., Yan, X., An, Y., Zhang, Y., & Tang, X. (2021). Multicentric Carpo-Tarsal Osteolysis Syndrome Mimicking Juvenile Idiopathic Arthritis: Two Case Reports and Review of the Literature. Frontiers in pediatrics, 9, 745812. https://doi.org/10.3389/fped.2021.745812
8. Chen, K., Zamariolli, M., Soares, M. F. F., Meloni, V. A., & Melaragno, M. I. (2022). Multicentric Carpotarsal Osteolysis Syndrome in a Mother and Daughter with a MAFB Missense Variant and Natural History of the Disease. Molecular syndromology, 13(1), 50–55. https://doi.org/10.1159/000517348.
9. Mehawej, C., Courcet, J. B., Baujat, G., Mouy, R., Gérard, M., Landru, I., Gosselin, M., Koehrer, P., Mousson, C., Breton, S., Quartier, P., Le Merrer, M., Faivre, L., & Cormier-Daire, V. (2013). The identification of MAFB mutations in eight patients with multicentric carpo-tarsal osteolysis supports genetic homogeneity but clinical variability. American journal of medical genetics. Part A, 161A(12), 3023–3029. https://doi.org/10.1002/ajmg.a.36151
10. Mumm, S., Huskey, M., Duan, S., Wenkert, D., Madson, K. L., Gottesman, G. S., Nenninger, A. R., Laxer, R. M., McAlister, W. H., & Whyte, M. P. (2014). Multicentric carpotarsal osteolysis syndrome is caused by only a few domain-specific mutations in MAFB, a negative regulator of RANKL-induced osteoclastogenesis. American journal of medical genetics. Part A, 164A(9), 2287–2293. https://doi.org/10.1002/ajmg.a.36641
11. Zankl A, Duncan EL, Leo PJ, Clark GR, Glazov EA, Addor MC, et al. Multicentric Carpotarsal Osteolysis Is Caused by Mutations Clustering in the Amino-Terminal Transcriptional Activation Domain of MAFB. Am J Hum Genet. 2012;90:494–501.
12. Sun K, Barlow B, Malik F, Inglis A, Figgie M, Goodman S. Total hip arthroplasty in a patient with multicentric carpotarsal osteolysis: a case report. HSS J. 2016;12:177–81.
13. Nishikomori, R., Kawai, T., Toshiyuki, K. et alet al. Remarkable improvement of articular pain by biologics in a Multicentric carpotarsal osteolysis patient with a mutation of MAFB gene.. Pediatr Rheumatol 13 (Suppl 1), P152 (2015). https://doi.org/10.1186/1546-0096-13-S1-P152
15. Regev, R., Sochett, E. B., Elia, Y., Laxer, R. M., Noone, D., Whitney-Mahoney, K., Filipowski, K., Shamas, A., & Vali, R. (2021). Multicentric carpotarsal osteolysis syndrome (MCTO) with generalized high bone turnover and high serum RANKL: Response to denosumab. Bone reports, 14, 100747. https://doi.org/10.1016/j.bonr.2021.100747
16. Klein, C., Bellity, J., Finidori, G. et alet al. Multicentric carpotarsal osteolysis syndrome: long-term follow-up of three patients. Skeletal Radiol 47, 1015–1019 (2018). https://doi.org/10.1007/s00256-018-2874-z
17. Ma, N. S., Mumm, S., Takahashi, S., & Levine, M. A. (2023). Multicentric Carpotarsal Osteolysis: a Contemporary Perspective on the Unique Skeletal Phenotype. In Current Osteoporosis Reports (Vol. 21, Issue 1, pp. 85–94). Springer. https://doi.org/10.1007/s11914-022-00762-7
18. Furness, L., Riley, P., Wright, N., Banka, S., Eyre, S., Jackson, A., & Briggs, T. A. (2022). Monogenic disorders as mimics of juvenile idiopathic arthritis. Pediatric Rheumatology, 20(1). https://doi.org/10.1186/s12969-022-00700-y
19. Bhavani, G. S., Shah, H., Shukla, A., Gupta, N., Gowrishankar, K., Rao, A. P., Kabra, M., Agarwal, M., Ranganath, P., Ekbote, A. v., Phadke, S. R., Kamath, A., Dalal, A., & Girisha, K. M. (2016). Clinical and mutation profile of multicentric osteolysis nodulosis and arthropathy. American Journal of Medical Genetics, Part A, 170(2), 410–417. https://doi.org/10.1002/ajmg.a.37447
20. Lerman, M. A., Francavilla, M., Waqar-Cowles, L., & Levine, M. A. (2023). Denosumab Treatment Does Not Halt Progression of Bone Lesions in Multicentric Carpotarsal Osteolysis Syndrome. JBMR Plus, 7(5). https://doi.org/10.1002/jbm4.10729
21. Ishaq, T., Loid, P., Ishaq, H. A., Seo, G. H., Mäkitie, O., & Naz, S. (2023). Clinical, radiographic and molecular characterization of two unrelated families with multicentric osteolysis, nodulosis, and arthropathy. BMC Musculoskeletal Disorders, 24(1). https://doi.org/10.1186/s12891-023-06856-2
22. Shakiba, M., & Alaei, F. (2023). A novel gene mutation for multicentric osteolysis nodulosis and arthropathy: Case report and review of literature. Heliyon, 9(4). https://doi.org/10.1016/j.heliyon.2023.e14865
23. Dusatkova, L., Potuznikova, K., Zemkova, D., Marik, I., Rozenkova, K., Lebl, J., Pruhova, S., & Sumnik, Z. (n.d.). Growth characteristics of a girl with multicentric carpo-tarsal osteolysis caused by novel mutation in the MAFB gene. https://doi.org/10.3252/pso.eu.55ESPE.2016
24. cndreas, Duncan, E. L., Leo, P. J., Clark, G. R., Glazov, E. A., Addor, M. C., Herlin, T., Kim, C. A., Leheup, B. P., McGill, J., McTaggart, S., Mittas, S., Mitchell, A. L., Mortier, G. R., Robertson, S. P., Schroeder, M., Terhal, P., & Brown, M. A. (2012). Multicentric carpotarsal osteolysis is caused by mutations clustering in the amino-terminal transcriptional activation domain of MAFB. American Journal of Human Genetics, 90(3), 494–501. https://doi.org/10.1016/j.ajhg.2012.01.003
25. Vanhoenacker, F. M., Simoni, P., Bosmans, F., & Boutry, N. (2021). Congenital and Developmental Abnormalities of the Hand and Wrist. In Seminars in Musculoskeletal Radiology (Vol. 25, Issue 2, pp. 260–271). Thieme Medical Publishers, Inc. https://doi.org/10.1055/s-0040-1722613
26. Faber, M. R., Verlaak, R., Fiselier, T. J. W., Hamel, B. C. J., Franssen, M. J. A. M., & Gerrits, G. P. J. M. (2004). Inherited multicentric osteolysis with carpal-tarsal localizationlocalisation mimicking juvenile idiopathic arthritis. European Journal of Pediatrics, 163(10), 612–618. https://doi.org/10.1007/s00431-004-1502-1
27. Faber, M. R., Verlaak, R., Fiselier, T. J. W., Hamel, B. C. J., Franssen, M. J. A. M., & Gerrits, G. P. J. M. (2004). Inherited multicentric osteolysis with carpal-tarsal localizationlocalisation mimicking juvenile idiopathic arthritis. European Journal of Pediatrics, 163(10), 612–618. https://doi.org/10.1007/s00431-004-1502-1
28. Miyazaki, K., Komatsubara, S., Uno, K., Fujihara, R., & Yamamoto, T. (2019). A CARE-compliant article: A case report of scoliosis complicated with multicentric carpotarsal osteolysis. Medicine (United States), 98(48). https://doi.org/10.1097/MD.0000000000017828
29. Thomas, C. W., Bisset, A. J., Sampson, M. A., & Armstrong, R. D. (2006). Multicentric carpal/tarsal osteolysis: imaging review and 25-year follow-up. Clinical Radiology, 61(10), 892–895. https://doi.org/10.1016/j.crad.2006.03.018
30. Zhuang, L., Adler, S., Aeberli, D., Villiger, P. M., & Trueb, B. (2017). Identification of a MAFB mutation in a patient with multicentric carpotarsal osteolysis. Swiss Medical Weekly, 147, w14529. https://doi.org/10.4414/smw.2017.14529
31. Somasekhara Aradhya A, Suri D, Prakash A. Multicentric Carpotarsal Osteolysis Mimicking Juvenile Idiopathic Arthritis. Int J Pediatr 2018; 6(11): 8605-9. DOI: 10.22038/ijp.2018.32810.2896
32. Trinkino, B., & Ma, N. S. (2023). Treatment of a young child with multicentric carpotarsal osteolysis exhibiting joint inflammation and dysfunctional bone formation. Bone Reports, 19. https://doi.org/10.1016/j.bonr.2023.101701
33. Lazarus, S., Tseng, H. W., Lawrence, F., Woodruff, M. A., Duncan, E. L., & Pettit, A. R. (2017). Characterization of Normal Murine Carpal Bone Development Prompts Re-Evaluation of Pathologic Osteolysis as the Cause of Human Carpal-Tarsal Osteolysis Disorders. American Journal of Pathology, 187(9), 1923–1934. https://doi.org/10.1016/j.ajpath.2017.05.007
34. Choochuen, P., Rojneuangnit, K., Khetkham, T., & Khositseth, S. (2018). The First Report of Multicentric Carpotarsal Osteolysis Syndrome Caused by MAFB Mutation in Asian. Case Reports in Medicine, 2018. https://doi.org/10.1155/2018/6783957
35. Drovandi, S., Lugani, F., Boyer, O., la Porta, E., Giordano, P., Hummel, A., Knebelmann, B., Cornet, J., Baujat, G., Lipska-Ziętkiewicz, B. S., Ghiggeri, G. M., Caridi, G., & Angeletti, A. (2022). Multicentric Carpotarsal Osteolysis Syndrome Associated Nephropathy: Novel Variants of MAFB Gene and Literature Review. Journal of Clinical Medicine, 11(15).
36. Tyler, T., Rosenbaum, H. D., & D4, M. (n.d.). IDIOPATHIC MULTICENTRIC OSTEOLYSIS*. www.ajronline.org
37. Bennett, W. M., Houghton, D. C., & Beals, R. C. (1980). Nephropathy of Idiopathic Multicentric Osteolysis. In Nephron (Vol. 25).
38. Shaik, L., Thotamgari, S. R., Kowtha, P., Ranjha, S., Shah, R. N., Kaur, P., Subramani, R., Katta, R. R., Kalaiger, A. mukhtadir, & Singh, R. (2021). A Spectrum of Pulmonary Complications Occurring in End-Stage Renal Disease Patients on Maintenance Hemodialysis. Cureus. https://doi.org/10.7759/cureus.15426
39. Mudgal P, Murphy A, Weerakkody Y, et al. Skeletal survey. Reference article, Radiopaedia.org (Accessed on 19 Nov 2023) https://doi.org/10.53347/rID-28346
1. Upadia, J., Gomes, A., Weiser, P., & Descartes, M. (2018). A Familial Case of Multicentric Carpotarsal Osteolysis Syndrome and Treatment Outcome. Journal of pediatric genetics, 7(4), 174–179. https://doi.org/10.1055/s-0038-1657760
2. Peeters, J., Vanhoenacker, F. M., Mortier, G., & Parizel, P. M. (2011). Multicentric carpal-tarsal osteolysis. JBR-BTR : organe de la Societe royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR), 94(4), 218. https://doi.org/10.5334/jbr-btr.641
3. Park, P. G., Kim, K. H., Hyun, H. S., Lee, C. H., Park, J. S., Kie, J. H., Choi, Y. H., Moon, K. C., & Cheong, H. I. (2018). Three cases of multicentric carpotarsal osteolysis syndrome: a case series. BMC medical genetics, 19(1), 164. https://doi.org/10.1186/s12881-018-0682-x
4. Mehawej, C., Courcet, J. B., Baujat, G., Mouy, R., Gérard, M., Landru, I., Gosselin, M., Koehrer, P., Mousson, C., Breton, S., Quartier, P., Le Merrer, M., Faivre, L., & Cormier-Daire, V. (2013). The identification of MAFB mutations in eight patients with multicentric carpo-tarsal osteolysis supports genetic homogeneity but clinical variability. American journal of medical genetics. Part A, 161A(12), 3023–3029. https://doi.org/10.1002/ajmg.a.36151
5. Wenkert, D., Mumm, S., Wiegand, S. M., McAlister, W. H., & Whyte, M. P. (2007). Absence of MMP2 mutation in idiopathic multicentric osteolysis with nephropathy. Clinical orthopedorthopaedics and related research, 462, 80–86. https://doi.org/10.1097/BLO.0b013e3180d09db8.
6. Dworschak, G. C., Draaken, M., Hilger, A., Born, M., Reutter, H., & Ludwig, M. (2013). An incompletely penetrant novel MAFB (p.Ser56Phe) variant in autosomal dominant multicentric carpotarsal osteolysis syndrome. International journal of molecular medicine, 32(1), 174–178. https://doi.org/10.3892/ijmm.2013.1373
7. Wu, J., Wang, L., Xu, Y., Zhang, Z., Yan, X., An, Y., Zhang, Y., & Tang, X. (2021). Multicentric Carpo-Tarsal Osteolysis Syndrome Mimicking Juvenile Idiopathic Arthritis: Two Case Reports and Review of the Literature. Frontiers in pediatrics, 9, 745812. https://doi.org/10.3389/fped.2021.745812
8. Chen, K., Zamariolli, M., Soares, M. F. F., Meloni, V. A., & Melaragno, M. I. (2022). Multicentric Carpotarsal Osteolysis Syndrome in a Mother and Daughter with a MAFB Missense Variant and Natural History of the Disease. Molecular syndromology, 13(1), 50–55. https://doi.org/10.1159/000517348.
9. Mehawej, C., Courcet, J. B., Baujat, G., Mouy, R., Gérard, M., Landru, I., Gosselin, M., Koehrer, P., Mousson, C., Breton, S., Quartier, P., Le Merrer, M., Faivre, L., & Cormier-Daire, V. (2013). The identification of MAFB mutations in eight patients with multicentric carpo-tarsal osteolysis supports genetic homogeneity but clinical variability. American journal of medical genetics. Part A, 161A(12), 3023–3029. https://doi.org/10.1002/ajmg.a.36151
10. Mumm, S., Huskey, M., Duan, S., Wenkert, D., Madson, K. L., Gottesman, G. S., Nenninger, A. R., Laxer, R. M., McAlister, W. H., & Whyte, M. P. (2014). Multicentric carpotarsal osteolysis syndrome is caused by only a few domain-specific mutations in MAFB, a negative regulator of RANKL-induced osteoclastogenesis. American journal of medical genetics. Part A, 164A(9), 2287–2293. https://doi.org/10.1002/ajmg.a.36641
11. Zankl A, Duncan EL, Leo PJ, Clark GR, Glazov EA, Addor MC, et al. Multicentric Carpotarsal Osteolysis Is Caused by Mutations Clustering in the Amino-Terminal Transcriptional Activation Domain of MAFB. Am J Hum Genet. 2012;90:494–501.
12. Sun K, Barlow B, Malik F, Inglis A, Figgie M, Goodman S. Total hip arthroplasty in a patient with multicentric carpotarsal osteolysis: a case report. HSS J. 2016;12:177–81.
13. Nishikomori, R., Kawai, T., Toshiyuki, K. et alet al. Remarkable improvement of articular pain by biologics in a Multicentric carpotarsal osteolysis patient with a mutation of MAFB gene.. Pediatr Rheumatol 13 (Suppl 1), P152 (2015). https://doi.org/10.1186/1546-0096-13-S1-P152
15. Regev, R., Sochett, E. B., Elia, Y., Laxer, R. M., Noone, D., Whitney-Mahoney, K., Filipowski, K., Shamas, A., & Vali, R. (2021). Multicentric carpotarsal osteolysis syndrome (MCTO) with generalized high bone turnover and high serum RANKL: Response to denosumab. Bone reports, 14, 100747. https://doi.org/10.1016/j.bonr.2021.100747
16. Klein, C., Bellity, J., Finidori, G. et alet al. Multicentric carpotarsal osteolysis syndrome: long-term follow-up of three patients. Skeletal Radiol 47, 1015–1019 (2018). https://doi.org/10.1007/s00256-018-2874-z
17. Ma, N. S., Mumm, S., Takahashi, S., & Levine, M. A. (2023). Multicentric Carpotarsal Osteolysis: a Contemporary Perspective on the Unique Skeletal Phenotype. In Current Osteoporosis Reports (Vol. 21, Issue 1, pp. 85–94). Springer. https://doi.org/10.1007/s11914-022-00762-7
18. Furness, L., Riley, P., Wright, N., Banka, S., Eyre, S., Jackson, A., & Briggs, T. A. (2022). Monogenic disorders as mimics of juvenile idiopathic arthritis. Pediatric Rheumatology, 20(1). https://doi.org/10.1186/s12969-022-00700-y
19. Bhavani, G. S., Shah, H., Shukla, A., Gupta, N., Gowrishankar, K., Rao, A. P., Kabra, M., Agarwal, M., Ranganath, P., Ekbote, A. v., Phadke, S. R., Kamath, A., Dalal, A., & Girisha, K. M. (2016). Clinical and mutation profile of multicentric osteolysis nodulosis and arthropathy. American Journal of Medical Genetics, Part A, 170(2), 410–417. https://doi.org/10.1002/ajmg.a.37447
20. Lerman, M. A., Francavilla, M., Waqar-Cowles, L., & Levine, M. A. (2023). Denosumab Treatment Does Not Halt Progression of Bone Lesions in Multicentric Carpotarsal Osteolysis Syndrome. JBMR Plus, 7(5). https://doi.org/10.1002/jbm4.10729
21. Ishaq, T., Loid, P., Ishaq, H. A., Seo, G. H., Mäkitie, O., & Naz, S. (2023). Clinical, radiographic and molecular characterization of two unrelated families with multicentric osteolysis, nodulosis, and arthropathy. BMC Musculoskeletal Disorders, 24(1). https://doi.org/10.1186/s12891-023-06856-2
22. Shakiba, M., & Alaei, F. (2023). A novel gene mutation for multicentric osteolysis nodulosis and arthropathy: Case report and review of literature. Heliyon, 9(4). https://doi.org/10.1016/j.heliyon.2023.e14865
23. Dusatkova, L., Potuznikova, K., Zemkova, D., Marik, I., Rozenkova, K., Lebl, J., Pruhova, S., & Sumnik, Z. (n.d.). Growth characteristics of a girl with multicentric carpo-tarsal osteolysis caused by novel mutation in the MAFB gene. https://doi.org/10.3252/pso.eu.55ESPE.2016
24. cndreas, Duncan, E. L., Leo, P. J., Clark, G. R., Glazov, E. A., Addor, M. C., Herlin, T., Kim, C. A., Leheup, B. P., McGill, J., McTaggart, S., Mittas, S., Mitchell, A. L., Mortier, G. R., Robertson, S. P., Schroeder, M., Terhal, P., & Brown, M. A. (2012). Multicentric carpotarsal osteolysis is caused by mutations clustering in the amino-terminal transcriptional activation domain of MAFB. American Journal of Human Genetics, 90(3), 494–501. https://doi.org/10.1016/j.ajhg.2012.01.003
25. Vanhoenacker, F. M., Simoni, P., Bosmans, F., & Boutry, N. (2021). Congenital and Developmental Abnormalities of the Hand and Wrist. In Seminars in Musculoskeletal Radiology (Vol. 25, Issue 2, pp. 260–271). Thieme Medical Publishers, Inc. https://doi.org/10.1055/s-0040-1722613
26. Faber, M. R., Verlaak, R., Fiselier, T. J. W., Hamel, B. C. J., Franssen, M. J. A. M., & Gerrits, G. P. J. M. (2004). Inherited multicentric osteolysis with carpal-tarsal localizationlocalisation mimicking juvenile idiopathic arthritis. European Journal of Pediatrics, 163(10), 612–618. https://doi.org/10.1007/s00431-004-1502-1
27. Faber, M. R., Verlaak, R., Fiselier, T. J. W., Hamel, B. C. J., Franssen, M. J. A. M., & Gerrits, G. P. J. M. (2004). Inherited multicentric osteolysis with carpal-tarsal localizationlocalisation mimicking juvenile idiopathic arthritis. European Journal of Pediatrics, 163(10), 612–618. https://doi.org/10.1007/s00431-004-1502-1
28. Miyazaki, K., Komatsubara, S., Uno, K., Fujihara, R., & Yamamoto, T. (2019). A CARE-compliant article: A case report of scoliosis complicated with multicentric carpotarsal osteolysis. Medicine (United States), 98(48). https://doi.org/10.1097/MD.0000000000017828
29. Thomas, C. W., Bisset, A. J., Sampson, M. A., & Armstrong, R. D. (2006). Multicentric carpal/tarsal osteolysis: imaging review and 25-year follow-up. Clinical Radiology, 61(10), 892–895. https://doi.org/10.1016/j.crad.2006.03.018
30. Zhuang, L., Adler, S., Aeberli, D., Villiger, P. M., & Trueb, B. (2017). Identification of a MAFB mutation in a patient with multicentric carpotarsal osteolysis. Swiss Medical Weekly, 147, w14529. https://doi.org/10.4414/smw.2017.14529
31. Somasekhara Aradhya A, Suri D, Prakash A. Multicentric Carpotarsal Osteolysis Mimicking Juvenile Idiopathic Arthritis. Int J Pediatr 2018; 6(11): 8605-9. DOI: 10.22038/ijp.2018.32810.2896
32. Trinkino, B., & Ma, N. S. (2023). Treatment of a young child with multicentric carpotarsal osteolysis exhibiting joint inflammation and dysfunctional bone formation. Bone Reports, 19. https://doi.org/10.1016/j.bonr.2023.101701
33. Lazarus, S., Tseng, H. W., Lawrence, F., Woodruff, M. A., Duncan, E. L., & Pettit, A. R. (2017). Characterization of Normal Murine Carpal Bone Development Prompts Re-Evaluation of Pathologic Osteolysis as the Cause of Human Carpal-Tarsal Osteolysis Disorders. American Journal of Pathology, 187(9), 1923–1934. https://doi.org/10.1016/j.ajpath.2017.05.007
34. Choochuen, P., Rojneuangnit, K., Khetkham, T., & Khositseth, S. (2018). The First Report of Multicentric Carpotarsal Osteolysis Syndrome Caused by MAFB Mutation in Asian. Case Reports in Medicine, 2018. https://doi.org/10.1155/2018/6783957
35. Drovandi, S., Lugani, F., Boyer, O., la Porta, E., Giordano, P., Hummel, A., Knebelmann, B., Cornet, J., Baujat, G., Lipska-Ziętkiewicz, B. S., Ghiggeri, G. M., Caridi, G., & Angeletti, A. (2022). Multicentric Carpotarsal Osteolysis Syndrome Associated Nephropathy: Novel Variants of MAFB Gene and Literature Review. Journal of Clinical Medicine, 11(15).
36. Tyler, T., Rosenbaum, H. D., & D4, M. (n.d.). IDIOPATHIC MULTICENTRIC OSTEOLYSIS*. www.ajronline.org
37. Bennett, W. M., Houghton, D. C., & Beals, R. C. (1980). Nephropathy of Idiopathic Multicentric Osteolysis. In Nephron (Vol. 25).
38. Shaik, L., Thotamgari, S. R., Kowtha, P., Ranjha, S., Shah, R. N., Kaur, P., Subramani, R., Katta, R. R., Kalaiger, A. mukhtadir, & Singh, R. (2021). A Spectrum of Pulmonary Complications Occurring in End-Stage Renal Disease Patients on Maintenance Hemodialysis. Cureus. https://doi.org/10.7759/cureus.15426
39. Mudgal P, Murphy A, Weerakkody Y, et al. Skeletal survey. Reference article, Radiopaedia.org (Accessed on 19 Nov 2023) https://doi.org/10.53347/rID-28346
How to Cite
1.
Albahkali S. Albahkali, et al The general skeletal features of Multicentric Carpotarsal Osteolysis: what the radiologist needs to know. Int J Med Res Rev [Internet]. 2024Jan.15 [cited 2024May17];11(6):146-58. Available from: https://ijmrr.medresearch.in/index.php/ijmrr/article/view/1454
Section
Review Article
Copyright (c) 2024 Author (s). Published by Siddharth Health Research and Social Welfare Society
This work is licensed under a Creative Commons Attribution 4.0 International License.
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