Histopathological Changes in Endometrial Biopsies of Patients with Abnormal Uterine Bleeding

  • Iman I Ali
  • Al-Shikey Ainour
  • Abouzrig Ghazala
  • Omar O. Ghazala
  • Arhoma Amal
  • AL-Gheryani, Nabeia,
Keywords: Abnormal uterine bleeding, Menopause, Endometrial hyperplasia

Abstract

Introduction: Abnormal uterine bleeding (AUB) is one of the commonest complaints leading to endometrial sampling by endometrial biopsy or curettage. Histopathological analysis revealed various patterns ranging from normal endometrium to malignancy and histopathological examination helps in the diagnosis of these diseases presenting with abnormal uterine bleeding. Objective: To assess the causes of AUB in reproductive, perimenopausal and menopausal women. Methodology: This is a retrospective study that includes a total of 375patients’specimens of endometrial biopsies which were clinically diagnosed as AUB in the department of pathology, faculty of medicine, the university of Benghazi from January 2009 to March 2010. The age of the patient ranged from 20 -80 years, and the mean age was (47.38yr). The patient was categorized into 3 groups with 198 cases in the perimenopausal age group,103 cases in the postmenopausal age group and only 74 cases in the reproductive age group. Results: in this study, the prevalence of non-neoplastic endometrial change was commonly seen in the perimenopausal and reproductive age groups (58.2%), (26.8%) respectively, whereas few cases in the postmenopausal age group (15%). The neoplastic endometrial changes (benign, premalignant, malignant) were commonly seen among the perimenopausal age group, followed by the postmenopausal age group, while neoplasia was rare in the reproductive age group. Conclusion: The causes of AUB depend on the age of the patient. In the reproductive age group, AUB was due to hormonal imbalance, while in perimenopausal and postmenopausal women it was generally due to hyperplasia and malignancy.

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References

1. Anthony M . Junqueiraʾs basic histology and atlas .14th ed . New York. McGraw-Hill Education; 2016.460 p.
2. M Kakar . Clinicopathological evaluation of abnormal uterine bleeding . J Health Res Rev:2015 ;62(2):45-9.
3. John W Ely, Colleen M Kennedy, Elizabeth C Clark . Abnormal uterine bleeding. The Journal of the American Board of Family Medicine. 2006 nov;19 (6) :590-602.
4. Rosai J . Ackerman’s .Surgical Pathology Text book of pathology.11th ed . Elsevier In:2013.440 p.
5. Vaidya S , Lakhey M , Amatya S . Histopathological pattern of abnormal uterine bleeding in endometrial biopsies. Nepal Medical College Journal. 2013;15(1):74– 77.
6. Abdullah LS . Histopathological pattern of endometrial sampling performed for Abnormal uterine bleeding . Bahrain Med Bull . 2011;33 (4):4-1.
7. Doraiswami S, Johnson T, Rao S . Study of endometrial pathology in abnormal uterine bleeding . J Obstetric Gynecol India. 2011;15 ( 1) :74– 77.
8. Zaino R. Abnormal proliferations, hyperplasia and polyps in interpretation of endometrial biopsies and curetting . Lippincott-Raven Publisher . 1996;59(8): 801–812.
9. Muzaffar M, Akhtar KAK, Yasmin S . Menstrual irregularities with excessive blood loss: a clinic- pathological correlation . J Pak Med Assoc . 2005;(8): 305-16.
10. Rosai J . Ackerman’s .Surgical Pathology Text book of pathology.9th ed . Elsevier Inc.2005. 990 p.
11. V Vijay , Ch J yothi , M Narsing Rao , V Sailaja , M.N.P Charan Paul. Study of histopathological pattern of endometrium in abnormal uterine bleeding. Saudi J Pathol Microbiol . 2017 ; 3 (4) :l-2 .
12. Tiwari A, kaur N, Jain S, Rai R, Jain S. Histopathological study of endometrial biopsy specimens for abnormal uterine bleeding . J Lumbini Med Coll . 2016 sep;8 (16):598-606.
13. Manisha Laddad , Nitin Kshirsagar , Sanjay Patil , Gauri Shinde . Study of adolescent abnormal uterine bleeding (AUB) and its outcome in tertiary centre . Akshantala Enterprises Private Limited . 2015nov;4 ( 69) :66-69.
14. Khan S, Hammed S, Umber A . Histopathological pattern of endometrium on diagnostic D&C in patients with abnormal uterine bleeding. KEMU . 2011;17(2): 166.
15. Naya K, Rekha Ratnani1, Naik Meena . A clinico-pathological analysis of causes of abnormal uterine bleeding . J Pathol Microbiol . 2017;20 (2):105-111.
16. Somboonporn , Padma SK, Shetty KJ . Study of histopathological patterns of endometrium in abnormal uterine bleeding . Journal of Health and Research. 2000 ;40(8): 815–819.
17. Cornitescu F, Tanase F , Simionescu F & Iliescu D . Clinical histopathological and therapeutic considerations in non-neoplastic abnormal uterine bleeding in menupause transition . Rom J Morphol Embryol. 2011;17(6):429-37.
18. Nabeia G, and Hanan M . Endometrial biopsies in female with abnormal uterine bleeding .pathology department Benghazi University . 2020;21(9):1-9.
17. Sajitha K . Study of histopathological pattern of endometrium in abnormal uterine bleeding . Journal of Health and Research. 2014 ;(1) :76-81.
18. Vaidya S, Lakhey M, Vaidya S . Histopathological pattern of abnormal uterine bleeding in endometrial biopsies. Nepal Med Coll J . 2013 ;64(29): 18-22.
19. Kurman RJ, Ellenson LH, Ronnett BM . Benign diseases of the endometrium . Mc Cluggage WG New York. Springer Verlag . 2011;17(2): 166.
20. Sajitha K . Study of histopathological pattern of endometrium in abnormal uterine bleeding . Journal of Health and Research . 2014; (1) :76-81.
21. Baral R , Pudasaini S. Histopathological pattern of endometrial samples in abnormal uterine bleeding. J Path Nepal. 2011;37 (4): 6 - 55.
22. Reed SD, Newton KM, Clinton WL, Epplein M, Garacia R, Allison K . Incidence of endometrial hyperplasia . Am J Obstet gynecol . 2009;(39):1297-1336.
23. Khan R, Sherwani RK, Rana . Clinico-pathological patterns in women with dysfunctional uterine bleeding . Iran J Pathol. 2016; (1):20-6.
24. Sahinoglu Z, Kuyumcuoglu U. An unusual case of postmenopausal vaginal bleeding retention of fetal bone. Arch Gynaecol . 2003;101 (18):1280-3.
25. Saraswathi D, Thanka J, Shalinee R . Study of endometrial pathology in abnormal uterine bleeding . Obstet Gynecol India. 2011; 61(4): 426–430.
How to Cite
1.
Ali II, Al-Shikey Ainour, Abouzrig Ghazala, Omar O. Ghazala, Arhoma Amal, AL-Gheryani, Nabeia,. Histopathological Changes in Endometrial Biopsies of Patients with Abnormal Uterine Bleeding. Int J Med Res Rev [Internet]. 2023Mar.30 [cited 2024Nov.22];11(1):10-7. Available from: https://ijmrr.medresearch.in/index.php/ijmrr/article/view/1415
Issue
Vol 11 No 1 (2023): Jan-Feb
Section
Original Article

Copyright (c) 2023 Author (s). Published by Siddharth Health Research and Social Welfare Society

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