Window of opportunity in axial spondyloarthritis: A Stitch in Time

  • Parasar Ghosh Professor and HOD, Department of Clinical Immunology and Rheumatology, Institute of Postgraduate Medical Educationand Research and SSKM Hospital, Kolkata, West Bengal, Indi
  • Pradip Kumar Sarma HOD, Department of Rheumatology and Clinical Immunology, Excel Care Hospital, Guwahati, Assam, India.
  • Padmanabha Shenoy Medical Director, Center For Arthritis and Rheumatism Excellence, Kerala, India
  • Dhrubojyoti Mukherjee Senior Medical Scientific Liaison, Novartis Healthcare Private Limited, India
  • Akshay Desai Franchise Medical Head, Novartis Healthcare Private Limited, India
Keywords: ankylosing spondylitis, axial spondyloarthritis, nonradiographic axial spondyloarthritis, magnetic resonance imaging, sacroiliac joint, sacroiliitis


Axial spondyloarthritis comprising both non-radiographic axial spondyloarthritis and ankylosingspondylitis has a deleterious impact on the patient’s quality of life with a detrimental outcome ofstructural damage. Although in the current era of diagnostic advancements, axSpA can be diagnosedearly within a short period after the onset of symptoms, but still there is a delay of up to severalyears in many parts of the world. The concept of a window of opportunity is primarily derived fromrheumatoid arthritis, which is relevant in the context of axSpA based upon the early diagnosis and tocommence highly effective treatment with biologics like anti-TNF and anti-IL-17 to modify thedisease process for arresting structural damage or syndesmophytes formation. Still, challenges existfor early diagnosis of SpA in patients with low back pain which ultimately creates a barrier toeffective treatment initiation. More robust researches along with the available evidence on both theaspects of clinical and imaging factors are the way forward for the early identification of susceptibleindividuals for early intervention with a better outcome.


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How to Cite
Parasar Ghosh, Pradip Kumar Sarma, Padmanabha Shenoy, Dhrubojyoti Mukherjee, Akshay Desai. Window of opportunity in axial spondyloarthritis: A Stitch in Time. Int J Med Res Rev [Internet]. 2022Nov.18 [cited 2022Nov.28];10(5):154-65. Available from:
Review Article