A Comparative Evaluation on the effect of Zinc-Probiotic combination versus Zinc alone therapy in children (3month-5year) with acute watery diarrhea attending the outpatient clinic of Sub-District hospital, Uttarakhand
Abstract
Background: Diarrhea is the major cause of morbidity and mortality among children worldwide. Various studies were done on the role of zinc therapy and probiotic therapy in reducing the duration and severity of acute watery diarrhea. This study aimed to compare the effect of Zinc –probiotic combination versus Zinc only therapy in acute watery diarrhea in pediatric patients.
Material and Methods: This was an open, randomized control trial in the pediatric outpatient department of Sub-District Female Hospital, Haldwani (Uttarakhand), from June 2020 till August 2020 for three months. Total 104 children aged six months to 5 years with acute diarrhea who met the inclusion criteria were enrolled and divided into 52 patients each. 1st Group A (n=52) received Zinc-Probiotics combination therapy, and 2ndGroup B (n=52) received Zinc only. Measurement of disease severity was based on the frequency of diarrhea (times/day) and duration of diarrhea (hours) after initial drug consumption. The resolution was assessed in mean remission time (time required to form solid stool from watery stool).
Result: Among the study population in group A, 62% were male, 38% were female, and in group B, 65% were male & 35% were female. Male predominance was observed in both groups. The mean frequency of diarrhea before treatment in Group A was 7.46 ± 4.1 times/day as compared to 6.69 ± 3.6 times/day in Group B. Mean duration of diarrhea in Group A was 53.5 ± 30.5 hours as compared to 57.6 ± 34.3 hours in Group B.
Conclusion: Combination therapy was more effective than Zinc only therapy in early remission and resolution of acute watery diarrhea in children.
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