Pulmonary function assessment in patients with type 2 diabetes mellitus
Abstract
Introduction: Diabetes mellitus is a leading public health problem all over the world. Diabetes mellitus is a risk factor that precipitating microvascular as well as macro-vascular pathologies. Several respiratory alterations have been reported in associations with Diabetes Mellitus. Therefore, the present study was designed to determine the effect of the disease on respiratory function in patients with diabetes.
Method & material: For this study 54 Diabetes Mellitus patients were selected using simple random sampling from the diabetic clinic. 54 Non-diabetic, age & sex-matched subjects were also taken from teaching and non-teaching employees of the hospital for comparison.
Result: In our study there was a statistically significant decrease in the level of FVC in DM patients compared to healthy male subjects. There was a statistically significant increase in the level of ratio of FEV1/FVC. A more sensitive index of early disease is FEV1/ FVC ratio.
Conclusion: Spirometric values were consistently lower in subjects with diabetes mellitus than in non-diabetics. Subjects with poorer diabetic control have a worse spirometric function. We conclude that strict glycaemic control & regular breathing exercises to strengthen the respiratory muscles may improve the pulmonary function test in patients.
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References
Khaled AA, Sekaran M, Ikram SI. Type 2 Diabetes and Vascular Complications: A pathophysiologic view. Biomedical Research 2010;21(2):147-55.
American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2009;32 Suppl 1(Suppl 1):S62-S67. doi:10.2337/dc09-S062.
King H, Aubert RE, Herman WH. Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. Diabetes Care. 1998 Sep;21(9):1414-31. doi: 10.2337/diacare.21.9.1414.
Benbassat CA, Stern E, Kramer M, Lebzelter J, Blum I, Fink G. Pulmonary function in patients with diabetes mellitus. Am J Med Sci. 2001 Sep;322(3):127-32. doi: 10.1097/00000441-200109000-00003. PMID: 11570776.
Kennedy WR, Navarro X, Sakuta M, Mandell H, Knox CK, Sutherland DE. Physiological and clinical correlates of cardiorespiratory reflexes in diabetes mellitus. Diabetes Care. 1989 Jun;12(6):399-408. Doi 10.2337/diacare.12.6.399.
Vinik AI, Maser ER, Mitchell BD, Freeman R. Diabetic autonomic neuropathy. Diabetes Care 2003 May; 26(5): 1553-1579.doi: 10.2337/diacare.26.5.1553.
Sandler M. Is the lung a 'target organ' in diabetes mellitus? Arch Intern Med. 1990 Jul;150(7):1385-8. PMID: 2196023.
Shah SH, Sonawane P, Nahar P, Vaidya S, Salvi S. Pulmonary function tests in type 2 diabetes mellitus and their association with glycemic control and duration of the disease. Lung India. 2013;30(2):108-112. doi:10.4103/0970-2113.11041.
Meo SA, Al-Drees AM, Shah SF, Arif M, Al-Rubean K. Lung function in type 1 Saudi diabetic patients. Saudi Med J. 2005 Nov;26(11):1728-33.
Meo SA, Al-Drees AM, Arif M, Al-Rubean K. Lung function in type 2 Saudi diabetic patients. Saudi Med J. 2006 Mar;27(3):338-43.
Melo E, Vianna EO, Gallo L Jr, Foss MC, Terra-Filho J. Pulmonary function, cholinergic bronchomotor tone, and cardiac autonomic abnormalities in type 2 diabetic patients. Braz J Med Biol Res. 2003 Mar;36(3):291-9. doi: 10.1590/s0100-879x2003000300002.
Hsia CC, Raskin P. Lung function changes related to diabetes mellitus. Diabetes Technol Ther. 2007 Jun;9 Suppl 1:S73-82. doi: 10.1089/dia.2007.0227.
Lange P, Parner J, Schnohr P, Jensen G. Copenhagen City Heart Study: longitudinal analysis of ventilatory capacity in diabetic and nondiabetic adults. Eur Respir J. 2002 Dec;20(6):1406-12. doi: 10.1183/09031936.02.00050502.
Alvin CP, Kasper DL, Fauci AS, Longo DL, Braunwald E, Hauser SL, Jameson LJ, editors. Harrison’s principles of Internal Medicine. Vol 2.16th edn. New York: McGraw Hill Companies 2005; 2152-2180.
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