A Rare Case of Fibrolamellar Hepatocellular Carcinoma with Unusual Presentation in a Young Indian Female- a case report
Keywords:
Fibrolamellar carcinoma, hepatocellular carcinoma, FLC, HCC
Abstract
Fibrolamellar carcinoma (FLC) is a rare subtype of Hepatocellular carcinoma (HCC) comprising Approx 1% of HCC. This variant of HCC commonly metastasizes to regional lymph nodes (celiac, gastric, para aortic). But metastasis to cervical lymph nodes is very rare. It is also very rare in Asian population. We are reporting a case of a rare cervical lymph node metastasis from FLC in an Indian female. Patient was a 20 yrs female presented with a cervical lymph node enlargement. USG and CT revealed lesion in liver and massive lymphadenopathy involving regional and para aortic group of lymph nodes. Diagnosis was made on histopathological examination of cervical lymph node biopsy.
Downloads
Download data is not yet available.
References
1. El-Serag HB, Davila JA. Is fibrolamellar carcinoma different from hepatocellular carcinoma? A US population-based study. Hepatology. Mar 2004; 39(3):798-803.
2. Edmondson HA. Differential diagnosis of tumors and tumor-like lesions of liver in infancy and childhood.AMA J Dis Child. Feb 1956; 91(2):168-86. [PubMed]
3. Craig JR, Peters RL, Edmondson HA, et al. Fibrolamellar carcinoma of the liver: a tumor of adolescents and young adults with distinctive clinico-pathologic features. Cancer. Jul 15 1980; 46(2):372-9.
4. Farhi DC, Shikes RH, Murari PJ, et al. Hepatocellular carcinoma in young people. Cancer. Oct 15 1983; 52(8):1516-25. [PubMed]
5. Berman MM, Libbey NP, Foster JH. Hepatocellular carcinoma. Polygonal cell type with fibrous stroma--an atypical variant with a favorable prognosis. Cancer. Sep 15 1980; 46(6):1448-55. [PubMed]
6. Vecchio FM. Fibrolamellar carcinoma of the liver: a distinct entity within the hepatocellular tumors. A review. Appl Pathol. 1988; 6(2):139-48. [PubMed]
7. O. Soreide, A. Czerniak, H. Bradpiece, S. Bloom, and L. Blumgart, “Characteristics of fibrolamellar hepatocellular carcinoma. a study of nine cases and a review of the literature,” American Journal of Surgery, vol. 151, no. 4, pp. 518–523, 1986.
8. Haratake J, Horie A. A histopathologic comparative study of European cases of Fibrolamellar carcinoma and Japanese cases of sclerosing hepatocellular carcinoma. Gan No Rinsho. 1989 Jun; 35(7):793-8.
9. Perez-Guillermo M, Masgrau NA, García-Solano J, et al. Cytologic aspect of fibrolamellar hepatocellular carcinoma in fine-needle aspirates. Diagn Cytopathol. Sep 1999; 21(3):180-7. [PubMed]
10. Gulati G, Saran RK. Fine needle aspiration cytology of fibrolamellar hepatocellular carcinoma: Recongnizing the oncocytic hepatocyte. Inian J Pathol Microbiol 2009; 52:288-9.
11. Ward SC, Waxman S. Fibrolamellar carcinoma: a review with focus on genetics and comparison to other malignant primary liver tumors. Semin Liver Dis. Feb 2011; 31(1):61-70. [PubMed]
12. Kakar S, Burgart LJ, Batts KP, et al. Clinicopathologic features and survival in fibrolamellar carcinoma: comparison with conventional hepatocellular carcinoma with and without cirrhosis. Mod Pathol. Nov 2005; 18(11):1417-23. [PubMed]
13. Singhal D, Vasdev N, Gupta S, Soin AS, Nayak NC, Nundy S. ¬Fibrolamellar hepatocellular carcinoma: Not a rare tumor in India and a possible new marker. J Gastroenterol Hepatol 2002; 17:A67. [PubMed]
14. Vaideeswar P, Pandit MJ, Deshpande JR, Sivaraman A, Vora IM. ¬Fibrolamellar carcinoma of the liver: An unusual presentation. J Postgrad Med 1993; 39:159-61.
2. Edmondson HA. Differential diagnosis of tumors and tumor-like lesions of liver in infancy and childhood.AMA J Dis Child. Feb 1956; 91(2):168-86. [PubMed]
3. Craig JR, Peters RL, Edmondson HA, et al. Fibrolamellar carcinoma of the liver: a tumor of adolescents and young adults with distinctive clinico-pathologic features. Cancer. Jul 15 1980; 46(2):372-9.
4. Farhi DC, Shikes RH, Murari PJ, et al. Hepatocellular carcinoma in young people. Cancer. Oct 15 1983; 52(8):1516-25. [PubMed]
5. Berman MM, Libbey NP, Foster JH. Hepatocellular carcinoma. Polygonal cell type with fibrous stroma--an atypical variant with a favorable prognosis. Cancer. Sep 15 1980; 46(6):1448-55. [PubMed]
6. Vecchio FM. Fibrolamellar carcinoma of the liver: a distinct entity within the hepatocellular tumors. A review. Appl Pathol. 1988; 6(2):139-48. [PubMed]
7. O. Soreide, A. Czerniak, H. Bradpiece, S. Bloom, and L. Blumgart, “Characteristics of fibrolamellar hepatocellular carcinoma. a study of nine cases and a review of the literature,” American Journal of Surgery, vol. 151, no. 4, pp. 518–523, 1986.
8. Haratake J, Horie A. A histopathologic comparative study of European cases of Fibrolamellar carcinoma and Japanese cases of sclerosing hepatocellular carcinoma. Gan No Rinsho. 1989 Jun; 35(7):793-8.
9. Perez-Guillermo M, Masgrau NA, García-Solano J, et al. Cytologic aspect of fibrolamellar hepatocellular carcinoma in fine-needle aspirates. Diagn Cytopathol. Sep 1999; 21(3):180-7. [PubMed]
10. Gulati G, Saran RK. Fine needle aspiration cytology of fibrolamellar hepatocellular carcinoma: Recongnizing the oncocytic hepatocyte. Inian J Pathol Microbiol 2009; 52:288-9.
11. Ward SC, Waxman S. Fibrolamellar carcinoma: a review with focus on genetics and comparison to other malignant primary liver tumors. Semin Liver Dis. Feb 2011; 31(1):61-70. [PubMed]
12. Kakar S, Burgart LJ, Batts KP, et al. Clinicopathologic features and survival in fibrolamellar carcinoma: comparison with conventional hepatocellular carcinoma with and without cirrhosis. Mod Pathol. Nov 2005; 18(11):1417-23. [PubMed]
13. Singhal D, Vasdev N, Gupta S, Soin AS, Nayak NC, Nundy S. ¬Fibrolamellar hepatocellular carcinoma: Not a rare tumor in India and a possible new marker. J Gastroenterol Hepatol 2002; 17:A67. [PubMed]
14. Vaideeswar P, Pandit MJ, Deshpande JR, Sivaraman A, Vora IM. ¬Fibrolamellar carcinoma of the liver: An unusual presentation. J Postgrad Med 1993; 39:159-61.
CITATION
DOI: 10.17511/ijmrr.2014.i04.21
Published: 2014-08-31
How to Cite
1.
Nayak R, Jain S. A Rare Case of Fibrolamellar Hepatocellular Carcinoma with Unusual Presentation in a Young Indian Female- a case report. Int J Med Res Rev [Internet]. 2014Aug.31 [cited 2024Jul.3];2(4):385-8. Available from: https://ijmrr.medresearch.in/index.php/ijmrr/article/view/124
Section
Case Report
OAI - Open Archives Initiative
