Comparative study of renal function test and thyroid hormone in chronic kidney disease

  • Nitesh Singhal Ph.D. Scholar, Department of Biochemistry, Medical College Kota, Rajasthan, India
  • Dr. R.D. Mathur Associate Professor, Department of Medicine, SRG Hospital and Jhalawar Medical College Jhalawar, Rajasthan, India
  • Dr. Ajay Kumar Bhargava Senior Professor, Department of Biochemistry, SRG Hospital and Jhalawar Medical College Jhalawar, Rajasthan, India
  • Dr. Deepak Gupta Senior Professor, Department of Medicine, SRG Hospital and Jhalawar Medical College Jhalawar, Rajasthan, India
Keywords: Chronic kidney disease (CKD), Thyroid hormone (T3, T4, TSH)

Abstract

Introduction: Biochemical parameters (urea, creatinine, uric acid, T3, T4, TSH) important in prognosis, monitoring of thyroid dysfunction, and chronic kidney disease. The present study was attempted to analyze these parameters in CKD patients and a healthy control group.

Materials and methods: Fifty healthy control and 5o were chronic kidney disease subjects were taken serum urea, creatinine uric acid analyzed on the auto analyzer and T3, T4, TSH estimated on immunoassay analyzer. Ethical permission was taken from the institutional ethical committee.

Results: Level of urea, creatinine, uric acid, and thyroid hormone T3, T4, TSH were found to be significant in the present study when compared with the control group. (Þ<0.0001).

Conclusion: It was observed that levels of urea, creatinine, uric acid, and T3, T4, TSH deranged value found in chronic kidney disease subjects.

Downloads

Download data is not yet available.

References

Langovan Veerappan and Georji Abraham, chapter 130 chronic kidney disease: Current status, challenges and management in India 2012:593.

Nitesh Singhal, Ajay Kumar Bhargava, Sushma Pandey. Study of thyroid hormone (T3,T4,TSH) level in dialyzed chronic kidney disease (CKD) patients. J Med Sci Clin Rese. 2019, 7(14):304-309. doi: 10.18535/jmscr/v7i4.53.

Brenner and Recturo’s. The Kidney. Rober A, Tenton, Jepee practorians. Anatomy of kidney. 11th ed, 2016.

Fauci B, Kasper, Braunwald Hauser, Longo. Harrison’s Principle of internal medicine, 17th ed, 2008.

Caroll LE. The Stage of chronic kidney disease and the estimate glomerular filtration rate. The Journal of Lancaster General Hospital. 2016;1(2):64-69.

Nisha R. Shrinivasakannan S R, Thango Merriappan K, Jagatha P. Biochemical evaluation of creatinine and urea in patients with renal failure undergoing hemodialysis Journal of Clinical Pathology and Laboratory Medicine 2017;1(2):151-155.

Rober K Murray, Daryl K, Granner petter A Mayar, Victor W Rodheel. In Harpers Biochemistry, 25th ed Lange Medical Publication. 2000.

Laurence M, Tierney, jr.stephen S MacPhee and maxim A, Popadakis. Current Medical Diagnosis & Treatment 43rd ed. 2004.

Rajagopalan B, Dolia PB, Arumalla VK, Seshadri Reddy V. Renal function markers and thyroid hormone status in undialyzed chronic kidney disease. Al Ameen J Med Sci. 2013;6(1):70-74.

Iglesias P, Díez JJ. Thyroid dysfunction and kidney disease. Europe J Endocrinol. 2009;16(2):204-213. doi: 10.1530/EJE-08-0837.

Wu, Alan H.B. Tietz Clinical Guide to Laboratory Tests. 4th edition. W.B. Saunders. 2006.

Mohandas R, Johnson R. Uric acid level increase risk for New-onset kidney disease. Am Soc Nephrol. 2008;19(12):2251-2253. doi: 10.1681/ASN.2008091012.

Srivastava S, Rajput J, Shrivastava M, Chandra R, Gupta M, Sharma R. Correlation of thyroid hormone profile with biochemical markers of renal function in patients undialysed chronic kidney disease. Indian J Endocrinol Metabol. 2018;22(33):316-320. doi: 10.4103/ijem.IJEM_475_17.

Basu G. Interaction between thyroid disorders and kidney disease. Indian Journal of Endocrinology and Metabolism. 2012;16(2):204-203. doi 10.4103/2230-8210.93737.

John E. Hall. Arthur C, Guyton. Textbook of Medical Physiology. Chapter 3. kidney disease and Diuretics. 11th ed. 2006. P: 402-415.

Mariani LH, Berns JS. The renal manifestations of thyroid disease. J Am Soc Nephrol. 2012; 23(1):22-26. doi: 10.1681/ASN2010070766.

Entedhar RS, Nawal AM. Biochemical changes in chronic renal failure pre- and post-hemodialysis. J Environ Sci Eng Technol. 2016;5:190-195.

Zoccali C, Tripepi G, Cutrupi S, Pizzini P, Mallamai F. Low triiodothyronine a new facet of inflammation in end stage renal disease. J AM Soc Nephrol. 2005;16(9):2789-2795. doi: 10.10, 1681/ASN/2005.

Zhou J, LI HB, XR Zhy XR, Song HL, Zhao YY, Yang JK. Subclinical hypothyroidism and the risk of chronic kidney disease in T2D subjects; A case control and dose response analysis. Medicine (Baltimore) 2017;96(15):e6519. doi: 10.1097/MD.0000000000006519.

CITATION
DOI: 10.17511/ijmrr.2020.i06.10
Published: 2020-12-31
How to Cite
1.
Nitesh Singhal, Dr. R.D. Mathur, Dr. Ajay Kumar Bhargava, Dr. Deepak Gupta. Comparative study of renal function test and thyroid hormone in chronic kidney disease. Int J Med Res Rev [Internet]. 2020Dec.31 [cited 2024Dec.22];8(6):429-33. Available from: https://ijmrr.medresearch.in/index.php/ijmrr/article/view/1234
Section
Original Article