Vitamin D3 effect on Albuminuria in Type 2 Diabetes Mellitus patients in Northern Andhra Pradesh, India

  • Dr. P. Sreedevi Assistant Professor, Department of General Medicine, Great Eastern Medical School and Hospital Ragolu, Srikakulam, Andhra Pradesh, India
  • Dr. B. Annaji Assistant Professor, Department of General Medicine, Great Eastern Medical School and Hospital Ragolu, Srikakulam, Andhra Pradesh, India
  • Dr. K. Sudheer Professor, Department of General Medicine, Great Eastern Medical School and Hospital Ragolu, Srikakulam, Andhra Pradesh, India
  • Dr. Tammineni Venugopal Assistant Professor, Department of General Medicine, Great Eastern Medical School and Hospital Ragolu, Srikakulam, Andhra Pradesh, India
Keywords: Albuminuria, RAS -Renin-Angiotensin System, T2DM-Type 2 Diabetes Mellitus, Vitamin D

Abstract

Introduction: Vitamin D deficiency is a common disorder in diabetic patients and may be a risk factor for the progression of diabetic nephropathy. The present study aimed to assess the effects of a large dose of parenteral. Vitamin D on 24 hours albuminuria in T2DM patients.

Methods: This prospective single-center study included 80 vitamin D deficient [25(OH) D <50 nmol/l] T2DM patients with an adequate glycemic control (HbA1c< 7.0%). Without any changes in anti-hyperglycemic or antihypertensive drugs, these patients were given a single high dose (600000 IU) of parenteral Vitamin D3. Then the changes in Vitamin D levels and 24 hours albuminuria were seen on follow up at 3 months.

Results: Vitamin D3 supplementation improved 24 hours albuminuria. In the present study, Twenty-four-hour urinary albumin excretion decreased from 210.4 ± 101.2 to 204.6 ± 104.5. In males, it changed from 221.8 ± 99.7 to 216.1 ± 100.3 and in females, it changed from 192.3 ± 108.5 to 186.7 ± 113.1. There was a negative association of albuminuria with Vit D levels in the present study.

Conclusion: Vitamin D3 supplementation significantly reduces 24-hour urinary albumin excretion in T2DM patients with Vitamin D3 deficiency.

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Published
2020-08-31
How to Cite
1.
Dr. P. Sreedevi, Dr. B. Annaji, Dr. K. Sudheer, Dr. Tammineni Venugopal. Vitamin D3 effect on Albuminuria in Type 2 Diabetes Mellitus patients in Northern Andhra Pradesh, India. Int J Med Res Rev [Internet]. 2020Aug.31 [cited 2020Sep.21];8(4):320-5. Available from: https://ijmrr.medresearch.in/index.php/ijmrr/article/view/1198
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Original Article