The sensitivity of electrodiagnostic criteria in subtype identification at the presentation in patients of Guillain-Barre syndrome

  • Dr. Neeharika L.Mathukumalli Assistant Professor, Department of Neurology, Nizam’s Institute of Medical Sciences, Hyderabad, Telangana, India
  • Dr. Sai Deepak Yaranagula Senior Resident, Department of Neurology, Nizam’s Institute of Medical Sciences, Hyderabad, Telangana, India
  • Dr. Meena A Kanikannan NIMS, Hyderabad, Telangana, India
  • Dr. Ramesh Chepuru Senior Resident, Department of Neurology, Nizam’s Institute of Medical Sciences, Hyderabad, Telangana, India
  • Dr. Sireesha Yareeda Assistant Professor, Department of Neurology, Nizam’s Institute of Medical Sciences, Hyderabad, Telangana, India
  • Sailaja Sarva Senior Lab Technologist, Department of Neurology, Nizam’s Institute of Medical Sciences, Hyderabad, Telangana, India
  • Dr. Rupam Borgohain Professor and Head of Department, DM Neurology, Department of Neurology, Nizam’s Institute of Medical Sciences, Hyderabad, Telangana, India
DOI: https://doi.org/10.17511/ijmrr.2020.i02.01
Keywords: Electrophysiology in GBS, Sensitivity of electrophysiological criteria in GBS, Guillain Barre syndrome, GBS, Electrodiagnostic criteria

Abstract

Introduction: Electrophysiology plays a pivotal role in identifying various GBS subtypes. Despite having many electrodiagnostic criteria,studies addressing their applicability in patients of GBS at diagnosis are quite a few.

Purpose: This study evaluates the sensitivity of 5 known electrophysiological criteria in patients with GBS at the time of presentation.

Material & Methods: Clinical and electrophysiological data of GBS patients admitted with us between January 2011 and December 2016 were collected retrospectively from our hospital database, compiled and analyzed. For each patient, 5 different criteria for the electrophysiological diagnosis of GBS were applied, and the sensitivity of these 5 criteria in the diagnosis was evaluated.

Results: A total of 288 patients were included. Closer concordance was noted between the criteria in diagnosing axonal subtype (Range- 36.81% to 41.32%).Italian criteria had the highest sensitivity (41.32%). There was a wider variation in the diagnosis of AIDP (Range- 19.79 to 34.72%). Hadden criteria showed the highest sensitivity (34.72%) closely followed by Ho et al (34.02%).

Conclusion: As the timing of Nerve Conduction Studies (NCS) and the severity of disease influence the grouping of each patient into a specific electrophysiologic subtype, one should be cautious in interpreting electrodiagnosticdata. Serial nerve conduction studies may be required to subtype each patient as electrophysiology evolves over the first few weeks of illness.

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CITATION
DOI: 10.17511/ijmrr.2020.i02.01
Published: 2020-04-30
How to Cite
1.
L.Mathukumalli N, Yaranagula SD, A Kanikannan DM, Chepuru R, Yareeda S, Sarva S, Borgohain R. The sensitivity of electrodiagnostic criteria in subtype identification at the presentation in patients of Guillain-Barre syndrome. Int J Med Res Rev [Internet]. 2020Apr.30 [cited 2024Apr.23];8(2):140-7. Available from: https://ijmrr.medresearch.in/index.php/ijmrr/article/view/1186
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Vol 8 No 2 (2020): Mar-Apr
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