Application of Thyroid Peroxidase (TPO) and Hector Battifora Mesothelial-1 (HBME-1) immunohistochemical markers in the diagnosis of papillary thyroid carcinoma of the thyroid

  • Dr. Vasundhara Singh Junior Resident, Department of Pathology, Government Medical College, Amritsar, Punjab, India
  • Dr. Permeet Kaur Bagga Associate Professor, Department of Pathology, Government Medical College, Amritsar, Punjab, India
  • Dr. Bikramjeet Singh Associate Professor, Department of Surgery, Government Medical College, Amritsar, Punjab, India
  • Dr Jaideep Assistant Professor, Department of Pathology, Government Medical College, Amritsar, Punjab, India
Keywords: TPO, HBME-1, Papillary Thyroid Carcinoma, Immunohistochemistry

Abstract

Background: Thyroid cancer is the most common endocrine malignancy accounting for >90% of malignancies of endocrine glands. The inter and intraobserver variation in the histomorphological diagnosis of Papillary Thyroid Carcinomas may sometimes pose a diagnostic difficulty. Application of IHC biomarkers may play an active or complementary role in their accurate classification.

Aim: The present study was conducted to evaluate if HBME-1 and TPO immunohistochemical analysis can reliably differentiate papillary carcinomas from other thyroid lesions.

Material and Methods: 50 cases of benign and malignant thyroid lesions were taken. Immunohistochemical staining for HBME-1 and TPO was performed. HBME-1 and TPO score was interpreted as absent and positive. Medical records were retrieved and their clinical data, surgical treatment, and pathological findings were noted.

Results: Out of 50 cases, 19 (73.1%) cases were diagnosed PTC, 4 (15.4%) cases were FTC, 3(11.5%) cases were of MTC and 24 cases of benign thyroid lesions. TPO expression was found positive in 91.7% of cases of Benign thyroid lesions. In malignant thyroid lesions, negative expression of TPO was seen in 63.16%, 0% and 33.33% of PTC, FCT, and MCT respectively. HBME-1 showed negative expression in 83.3% of cases of benign thyroid lesions. Whereas, in malignant thyroid lesion HBME-1 expression was positive in 78.95%, 50% and 0% cases of PTC, FCT, and MCT respectively.

Conclusion: Testing for expression of HBME-1 has been shown to improve the diagnostic accuracy for thyroid malignant nodules. The combination of HBME-1, and TPO may contribute to an accurate diagnosis of papillary thyroid carcinoma.

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CITATION
DOI: 10.17511/ijmrr.2020.i01.17
Published: 2020-02-29
How to Cite
1.
Singh V, Kaur Bagga P, Singh B, Jaideep. Application of Thyroid Peroxidase (TPO) and Hector Battifora Mesothelial-1 (HBME-1) immunohistochemical markers in the diagnosis of papillary thyroid carcinoma of the thyroid. Int J Med Res Rev [Internet]. 2020Feb.29 [cited 2024Oct.14];8(1):110-7. Available from: https://ijmrr.medresearch.in/index.php/ijmrr/article/view/1111
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